Evidence map›Paper›PMID 37339052›Full record

ArticleCell reports2023

Polysialylation controls immune function of myeloid cells in murine model of pneumococcal pneumonia.

Prajakta Shinde, Alexander Kiepas, Lei Zhang, Shreya Sudhir, Konstantinos Konstantopoulos, Nicholas M Stamatos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Prajakta ShindeInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Alexander KiepasDepartment of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Lei ZhangInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Shreya SudhirInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Konstantinos KonstantopoulosDepartment of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Nicholas M StamatosInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: nstamatos@ihv.umaryland.edu.
University of Maryland, Baltimore · USJohns Hopkins University · US

Funding

The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasisR01CA254193 · NCI · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS, MARTIN, STUART S · 2021 to 2025
$2.7M
Influence of polysialic acid on leukocyte migrationR01AI132733 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI STAMATOS, NICHOLAS MILTON · 2018 to 2022
$2.6M
The Role of Hydraulic Pressure in the Osmotic Engine Model of Cell MigrationR01GM134542 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SEAN X SUN · 2019 to 2026
$2.1M
NCI NIH HHS R01 CA254193NIAID NIH HHS R01 AI132733NIGMS NIH HHS R01 GM134542
6 · The paper itself

Abstract

Polysialic acid (polySia) is a post-translational modification of a select group of cell-surface proteins that guides cellular interactions. As the overall impact of changes in expression of this glycan on leukocytes during infection is not known, we evaluate the immune response of polySia-deficient ST8SiaIV

Indexed as

Pneumonia, PneumococcalAnimalsDisease Models, AnimalImmunityMiceMyeloid CellsSialic AcidsStreptococcus pneumoniaepolysialic acidSialic AcidsCP: Immunologyextracellular signal-regulated kinase ERK1/2intravital microscopyleukocyte migrationmicrofluidic migration chambersmonocytesneutrophilsphagocytosispolysialic acidpolysialyltransferase ST8SiaIVStreptococcus pneumoniae

Identifiers

PMID37339052
PMCPMC10592499
OpenAlexW4381251839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.