Evidence map›Paper›PMID 37338980›Full record

ArticleeLife2023

Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal

Maria I Lazaro-Pena, Adam B Cornwell, Carlos A Diaz-Balzac, Ritika Das, Zachary C Ward, Nicholas Macoretta, Juilee Thakar, Andrew V Samuelson

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Loss ofbioRxiv : the preprint server for biology · 2026
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  8. ConsideringCells · 2024
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maria I Lazaro-PenaDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, United States.ORCID 0000-0002-3061-8835
Adam B CornwellDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, United States.ORCID 0000-0002-0572-3107
Carlos A Diaz-BalzacDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, United States.ORCID 0000-0002-4723-1282
Ritika DasDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, United States.
Zachary C WardDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, United States.
Nicholas MacorettaDepartment of Biology, University of Rochester, Rochester, United States.
Juilee ThakarDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, United States.
Andrew V SamuelsonDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, United States.ORCID 0000-0002-3071-5766
University of Rochester Medical Center · USUniversity of Rochester · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Transcriptional control of proteostasis and agingRF1AG062593 · NIA · UNIVERSITY OF ROCHESTER · PI SAMUELSON, ANDREW VAUGHN · 2019 to 2022
$2.2M
Transcriptional regulation of neural circuit formation in intellectual disabilitiesF32HD105323 · NICHD · UNIVERSITY OF ROCHESTER · PI DIAZ-BALZAC, CARLOS ANTONIO · 2021 to 2023
$168k
NIA NIH HHS RF1 AG062593NIA NIH HHS RF1AG062593NICHD NIH HHS F32 HD105323NIH HHS F32HD105323NIH HHS P40 OD010440
6 · The paper itself

Abstract

Aging and the age-associated decline of the proteome is determined in part through neuronal control of evolutionarily conserved transcriptional effectors, which safeguard homeostasis under fluctuating metabolic and stress conditions by regulating an expansive proteostatic network. We have discovered the

Indexed as

Caenorhabditis elegans ProteinsLongevityAgingAnimalsCaenorhabditis elegansGABAergic NeuronsGene Expression RegulationHomeodomain ProteinsHomeostasisProtein KinasesCaenorhabditis elegans ProteinsHomeodomain ProteinsProtein KinasesagingC. elegansgene expressiongeneticsgenomicshomeodomain-interacting protein kinaselongevityneuronal cell non-autonomous controlneuroscienceproteostasis

Identifiers

PMID37338980
PMCPMC10393298
OpenAlexW4381308515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.