Evidence map›Paper›PMID 37338788›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2023

Topical formulations containing Trichilia catigua extract as therapeutic options for a genital and an acyclovir-resistant strain of herpes recurrent infection.

Elisa Vicente Ribelato, Jéssica Wouk, Gabriela Gomes Celestino, Bianca Cerqueira Dias Rodrigues, Maria Laura Goussain Darido, Mario Gabriel Lopes Barboza, Tatiana Jabor Botura, Maylla Cardoso de Oliveira, Fábio Goulart de Andrade, Audrey A S G Lonni and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Elisa Vicente RibelatoLaboratório de Virologia, Departamento de Microbiologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
Jéssica WoukLaboratório de Virologia, Departamento de Microbiologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
Gabriela Gomes CelestinoLaboratório de Virologia, Departamento de Microbiologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
Bianca Cerqueira Dias RodriguesLaboratório de Virologia, Departamento de Microbiologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
Maria Laura Goussain DaridoLaboratório de Virologia, Departamento de Microbiologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
Mario Gabriel Lopes BarbozaLaboratório de Virologia, Departamento de Microbiologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
Tatiana Jabor BoturaLaboratório de Virologia, Departamento de Microbiologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
Maylla Cardoso de OliveiraDepartamento de Histologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
Fábio Goulart de AndradeDepartamento de Histologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
Audrey A S G LonniDepartamento de Ciências Farmacêuticas-Centro de Ciências da Saúde, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
João Carlos Palazzo de MelloLaboratório de Biologia Farmacêutica, Palafito, Departamento de Farmácia, Universidade Estadual de Maringá (UEM), Maringá, Paraná, Brazil.
Sérgio Paulo Dejato da RochaLaboratório de Virologia, Departamento de Microbiologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil.
Lígia C Faccin-GalhardiLaboratório de Virologia, Departamento de Microbiologia-Centro de Ciências Biológicas, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil. lgalhardi@uel.br.ORCID http://orcid.org/0000-0002-7522-9710
Universidade Estadual de Londrina · BRUniversidade Estadual de Maringá · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88882.448103/2019-01
6 · The paper itself

Abstract

Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infect, respectively, 67% and 13% of the world population, most commonly causing mild symptoms, such as blisters/ulcers. However, severe conditions such as keratitis, encephalitis, and systemic infections may occur, generally associated with the patient's immunological condition. Although Acyclovir® (ACV) and its analogs are the reference drugs for herpetic infections, the number of ACV-resistant HSV infections is growing exponentially. Therefore, new natural products' bioactive compounds have been studied to develop novel effective anti-herpetics. Trichilia catigua is a plant widely used in traditional medicine, including the treatment of skin diseases and sexual infections. In our study, 16 extracts from the bark of T. catigua, obtained with different solvents and their combinations, were evaluated against HSV-1 AR and HSV-2, respectively, ACV resistance and genital strains in vitro. The extracts with the highest selectivity index were used to prepare new topical anti-herpetic formulations and confirmed in vivo. Two new topical formulations were suggested to treat cutaneous and genital herpetic recurrent lesions. The cytotoxicity and antiviral activity were tested using the MTT method. The cytotoxic (CC

Indexed as

Herpes SimplexHerpesvirus 1, HumanMeliaceaeAcyclovirAnimalsAntiviral AgentsGenitaliaHerpesvirus 2, HumanMiceReinfectionAcyclovirAntiviral AgentsGenital HSV-2HSV-1 acyclovir-resistant strainIn vitro and in vivo evaluationsTopical formulationsTrichilia catigua

Identifiers

PMID37338788
PMCPMC10485181
OpenAlexW4381309339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.