Evidence map›Paper›PMID 37338705›Full record

ReviewAdvances in neurobiology2023

Clinical Implications of Dystonia as a Neural Network Disorder.

Giovanni Battistella, Kristina Simonyan

Registry-linked trialAbstract readReview
In one paragraph

Review in Advances in neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03042962 (Brain Networks in Dystonia), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03042962 recruitingnot on this map

Brain Networks in Dystonia

TypeobservationalSponsorMassachusetts Eye and Ear InfirmaryRan2015 to 2027Enrolled141ConditionsSpasmodic Dysphonia, Singer's Dystonia, Writer's Cramp, Musician's Focal Hand DystoniaArmsMRI, Blood draw
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Abnormal Brain Iron Metabolism is Linked to Altered Neural Function in Isolated Laryngeal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Giovanni BattistellaDepartment of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Kristina SimonyanDepartment of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA. kristina_simonyan@meei.harvard.edu.

Funding

Understanding disorder-specific neural pathophysiology in laryngeal dystonia and voice tremorP50DC019900 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Kristina Simonyan · 2021 to 2026
$11.9M
Imaging genetics of spasmodic dysphoniaR01DC011805 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Kristina Simonyan · 2012 to 2026
$8.8M
Voice tremor in spasmodic dysphonia: central mechanisms and treatment responseR01DC012545 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI SIMONYAN, KRISTINA · 2012 to 2021
$5.2M
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated DystoniaR01NS124228 · NINDS · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Kristina Simonyan · 2022 to 2026
$2.7M
Brain Networks in DystoniaR01NS088160 · NINDS · MASSACHUSETTS EYE AND EAR INFIRMARY · PI SIMONYAN, KRISTINA · 2015 to 2019
$2.4M
Adaptive closed-loop brain-computer interface therapeutic intervention in laryngeal dystoniaR01DC019353 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI SIMONYAN, KRISTINA · 2021 to 2025
$1.8M
Role of neurotransmission and functional CNS networks in spasmodic dysphoniaR00DC009629 · NIDCD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SIMONYAN, KRISTINA · 2009 to 2012
$955k
NIDCD NIH HHS P50 DC019900NIDCD NIH HHS R00 DC009629NIDCD NIH HHS R01 DC011805NIDCD NIH HHS R01 DC012545NIDCD NIH HHS R01 DC019353NINDS NIH HHS R01 NS088160NINDS NIH HHS R01 NS124228
6 · The paper itself

Abstract

Isolated dystonia is a neurological disorder of diverse etiology, multifactorial pathophysiology, and wide spectrum of clinical presentations. We review the recent neuroimaging advances that led to the conceptualization of dystonia as a neural network disorder and discuss how current knowledge is shaping the identification of biomarkers of dystonia and the development of novel pharmacological therapies.

Indexed as

ConnectomeDystoniaDystonic DisordersBrainHumansMagnetic Resonance ImagingConnectomeFunctional connectivityNetwork disorderNeurotransmissionStructural networks

Identifiers

PMID37338705
PMCPMC10319344

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.