SynthesisRheumatology international2023
Femoral head avascular necrosis in COVID-19 survivors: a systematic review.
Synthesis in Rheumatology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Arthroscopic assisted versus open core decompression for osteonecrosis of the femoral head: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Chinese clinical practice guidelines for minimally invasive hip preservation techniques for femoral head osteonecrosis (2025 edition).International orthopaedics · 2026Review
- Multifocal Osteonecrosis in the Hips and Shoulders Bilaterally after Severe COVID-19 Infection Misdiagnosed as Fibromyalgia: A Case Report.Journal of orthopaedic case reports · 2026Article
- Changes in sexual health following total hip arthroplasty in heterosexual patients with stiff hips and their partners: a retrospective study.Frontiers in medicine · 2026Article
- Proportion of Avascular Necrosis of Femoral Head in Coronavirus Disease 19 Patients.Annals of African medicine · 2026Article
- Autologous bone marrow mononuclear cell transplantation for osteonecrosis of the femoral head in post-covid-19 syndrome: A case series.Regenerative therapy · 2025Article
- Exploring the Association Between COVID-19 and Avascular Necrosis: A Systematic Review.Cureus · 2025Review
- Letter to the editor regarding "osteonecrosis of the femoral head in post-COVID-19 patients: a retrospective comparative study".Journal of orthopaedic surgery and research · 2025Article
- Characteristics of osteonecrosis of the femoral head after COVID-19 steroid treatment compared to steroid-associated osteonecrosis.BMC musculoskeletal disorders · 2025Article
- Osteonecrosis of the femoral head in post-COVID-19 patients: a retrospective comparative study.Journal of orthopaedic surgery and research · 2025Article
- Is there an Increase in Total Hip Arthroplasty Due to Osteonecrosis of Femoral Head After Covid-19 Pandemic?: A Retrospective Study Among Patients in Central Karnataka, India.Journal of orthopaedic case reports · 2025Article
- Functional and HIP survivorship outcomes of free Vascularized fibula graft in the management of post COVID-19 Osteonecrosis of femur head: A prospective case series.Journal of orthopaedics · 2025Article
- Exploring the Association between COVID-19 and Femoral Head Necrosis: A Comprehensive Review.Life (Basel, Switzerland) · 2024Article
- Sexual activity at 1 year after total hip arthroplasty in Indian patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Outcome of Physiotherapy Treatment on a 28-Year-Old Male Diagnosed With Avascular Necrosis.Cureus · 2023Article
- Long COVID: the time has come for globally acceptable definitions.Rheumatology international · 2023Article
- Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current systematic review aimed to document published cases of femoral head avascular necrosis (FHAVN) post-COVID-19, to report the COVID-19 disease characteristics and management patients received, and to evaluate how the FHAVN were diagnosed and treated among various reports. A systematic literature review was performed per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines through a comprehensive English literature search on January 2023 through four databases (Embase, PubMed, Cochrane Library, and Scopus), including studies reporting on FHAVN post-COVID-19. Fourteen articles were included, ten (71.4%) were case reports, and four (28.6%) case series reported on 104 patients having a mean age of 42.2 ± 11.7 (14:74) years, in which 182 hip joints were affected. In 13 reports, corticosteroids were used during the COVID-19 management plan for a mean of 24.8 ± 11 (7:42) days, with a mean prednisolone equivalent dose of 1238.5 ± 492.8 (100:3520) mg. A mean of 142.1 ± 107.6 (7:459) days passed between COVID-19 diagnosis and FHAVN detection, and most of the hips were stage II (70.1%), and concomitant septic arthritis was present in eight (4.4%) hips. Most hips (147, 80.8%) were treated non-surgically, of which 143 (78.6%) hips received medical treatment, while 35 (19.2%) hips were surgically managed, 16 (8.8%) core decompression, 13 (7.1%) primary THA, five (2.7%) staged THA and three (1.6%) had first stage THA (debridement and application of antibiotic-loaded cement spacer). The outcomes were acceptable as regards hip function and pain relief. Femoral head avascular necrosis post-COVID-19 infection is a real concern, primarily attributed to corticosteroid usage, besides other factors. Early suspicion and detection are mandatory, as conservative management lines are effective during early stages with acceptable outcomes. However, surgical intervention was required for progressive collapse or patients presented in the late stage.
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Registered trials
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