Evidence map›Paper›PMID 37338642›Full record

ArticlePediatric nephrology (Berlin, Germany)2023

Association between serum total cholesterol and chronic kidney disease progression in children: results from the KNOW-PedCKD.

Hee Sun Baek, Min Ji Park, Ji Yeon Song, Seong Heon Kim, Hee Gyung Kang, Yo Han Ahn, Kyoung Hee Han, Heeyeon Cho, Keum Hwa Lee, Jae Il Shin and 5 more

Abstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hee Sun BaekDepartment of Pediatrics, Yeungnam University, College of Medicine, Daegu, South Korea.
Min Ji ParkDepartment of Pediatrics, Kyungpook National University, School of Medicine, Daegu, South Korea.
Ji Yeon SongDepartment of Pediatrics, Pusan National University Children's Hospital, Pusan National University, School of Medicine, Busan, South Korea.
Seong Heon KimDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
Hee Gyung KangDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
Yo Han AhnDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.
Kyoung Hee HanDepartment of Pediatrics, Jeju National University Hospital, Jeju, South Korea.
Heeyeon ChoDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Keum Hwa LeeDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea.
Jae Il ShinDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea.
Young Seo ParkDepartment of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea.
Joo Hoon LeeDepartment of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea.
Eujin ParkDepartment of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea.
Eun Mi YangDepartment of Pediatrics, Chonnam National University Hospital, Gwangju, South Korea.
Min Hyun ChoDepartment of Pediatrics, Kyungpook National University, School of Medicine, Daegu, South Korea. chomh@knu.ac.kr.ORCID http://orcid.org/0000-0002-7965-7587

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDyslipidemia can cause cardiovascular disease and increase the fatality rate among children with chronic kidney disease (CKD); this makes early screening and treatment of dyslipidemia crucial. This study aimed to assess the association between the changes in serum total cholesterol levels over time and the degree of CKD progression in children.

methodsFrom April 2011 to August 2021, 379 of the 432 participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric CKD (KNOW-PedCKD) were included and divided into 4 categories based on total cholesterol levels (< 170 mg/dL, acceptable; 170-199, borderline; 200-239, high; and ≥ 240, very high). Survival analysis using conventional and time-dependent Cox proportional hazards model were performed for a composite event of CKD progression (≥ 50% decrease in estimated glomerular filtration rate from baseline, a twofold increase in creatinine, or the occurrence of dialysis or kidney transplantation).

resultThe incidence of composite event of CKD progression was 96.3, 90.4, 87.3, and 270.6 cases per 1000 person-years in the acceptable, borderline, high, and very high categories, respectively. On using the time-dependent Cox proportional hazards model, the hazard ratio of the very high category was significantly higher than that of the acceptable category by 3.13 times as per univariate analysis and 2.37 times as per multivariate analysis.

conclusionsVery high serum total cholesterol is a significant risk factor for CKD progression in children. Lowering total cholesterol levels below the very high category in children with CKD may delay the progression of CKD. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

DyslipidemiasRenal Insufficiency, ChronicChildCholesterolCohort StudiesDisease ProgressionGlomerular Filtration RateHumansRenal DialysisRisk FactorsCholesterolCardiovascular diseaseChildrenChronic kidney diseaseCKD progressionDyslipidemiaTotal cholesterol

Identifiers

PMID37338642

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.