Evidence map›Paper›PMID 37338607›Full record

ArticleMikrochimica acta2023

Enzymatic reaction modulated DNA assembly on graphitic carbon nitride nanosheets for sensitive fluorescence detection of acetylcholinesterase activity and inhibition.

Tingting Chen, Yingfeng Qin, Beibei Wang, Rongji Lai, Guohe Tan, Jin-Wen Liu

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tingting ChenDepartment of Human Anatomy, Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, Guangxi Health Commission Key Laboratory of Basic Research on Brain Function and Disease, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China.
Yingfeng QinKey Laboratory of Biological Molecular Medicine Research (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, People's Republic of China. qinyingfeng@sr.gxmu.edu.cn.
Beibei WangKey Laboratory of Biological Molecular Medicine Research (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, People's Republic of China.
Rongji LaiKey Laboratory of Biological Molecular Medicine Research (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, People's Republic of China.
Guohe TanDepartment of Human Anatomy, Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, Guangxi Health Commission Key Laboratory of Basic Research on Brain Function and Disease, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China. tanguohe@gxmu.edu.cn.
Jin-Wen LiuKey Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Nanning, 530021, Guangxi, People's Republic of China. jinwenliu@hnu.edu.cn.ORCID http://orcid.org/0000-0001-9340-8109
Guangxi Medical University · CNGuangxi University · CN

Funding

National Natural Science Foundation of China 22266007The Basic Ability Enhancement Program for Young and Middle-aged Teachers of Guangxi 2022KY0098the Project of Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University 02304001020X
6 · The paper itself

Abstract

A novel fluorescent strategy has been developed by using an enzymatic reaction modulated DNA assembly on graphitic carbon nitride nanosheets (CNNS) for the detection of acetylcholinesterase (AChE) activity and its inhibitors. The two-dimensional and ultrathin-layer CNNS-material was successfully synthesized through a chemical oxidation and ultrasound exfoliation method. Because of its excellent adsorption selectivity to ssDNA over dsDNA and superior quenching ability toward the fluorophore labels, CNNS were employed to construct a sensitive fluorescence sensing platform for the detection of AChE activity and inhibition. The detection was based on enzymatic reaction modulated DNA assembly on CNNS, which involved the specific AChE-catalyzed reaction-mediated DNA/Hg

Indexed as

AcetylcholinesteraseGraphiteDNAFluorescenceHumansNitrogen CompoundsAcetylcholinesteraseDNAGraphitegraphitic carbon nitrideNitrogen CompoundsAcetylcholinesteraseDNA assemblyEnzymatic reactionGraphitic carbon nitride nanosheets (CNNS)Inhibitor screening

Identifiers

PMID37338607
OpenAlexW4381309364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.