ArticleEuropean radiology2023
Trends in the incidence of pulmonary nodules in chest computed tomography: 10-year results from two Dutch hospitals.
Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 57 citations in OpenAlex.
- Chest CT-detected pulmonary nodules across the COVID-19 pandemic in Guangzhou, China: a regression discontinuity-in-time study, 2013-2023.Translational lung cancer research · 2026Article
- Health Insurance Type and Lung Cancer Stage Shift Following Coverage of Screening.Health services research · 2026Article
- Features of low-dose CT-detected lung nodules: individuals who never smoked vs. who smoke(d) in a Chinese general population.European radiology · 2026Article
- Deep learning-based malignancy probability estimation of pulmonary nodules in PET/CT imaging.European radiology · 2026Article
- Diagnostic uncertainty and addiction-like reassurance seeking in patients with pulmonary nodules: a cross-sectional study.Journal of thoracic disease · 2026Article
- A narrative review on CT-based evaluation and prediction of lung nodule growth: current status and future directions.Translational lung cancer research · 2026Review
- Preoperative and intraoperative localization of small pulmonary nodules for thoracoscopic surgery: a contemporary narrative review.Journal of robotic surgery · 2026Review
- Is This Calculator Broken?: Comparative Performance of Lung Nodule Risk Assessment Calculators in a High-Prevalence Cohort.CHEST pulmonary · 2026Article
- Early Individualized Psychological Intervention Using Virtual Reality-assisted Decision System Reduces Decisional Conflict in Patients with Pulmonary Nodules: A Randomized Controlled Trial.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Single-nucleus sequencing dissects the malignant change of early lung adenocarcinoma: SMAD3 suppresses antitumor T cell immunity via ICAM1.NPJ precision oncology · 2026Article
- [DGP and ÖGP Congress 2025: Highlights from Interventional Pulmonology].Pneumologie (Stuttgart, Germany) · 2026Article
- Dye Localization Extended Segmentectomy vs. Lobectomy for Deep Intersegmental Early-Stage Lung Cancer.Diagnostics (Basel, Switzerland) · 2026Article
- From detection to decision: Can deep learning-based CADx meet the challenge of incidental pulmonary nodules?European radiology · 2026Article
- Clinical applications of deep learning in distinguishing benign from malignant pulmonary nodules in computed tomography scans.Archives of medical science : AMS · 2026Article
- Incidence of Second Primaries and Recurrent Disease in Early-Stage Lung Cancer: What Can We Expect in a Nodule-Care Center Cohort?Respiration; international review of thoracic diseases · 2026Article
- Incidental Pulmonary Nodules: What Should We Do in 2026?Respiration; international review of thoracic diseases · 2026Review
- Performance of a screening-trained DL model for pulmonary nodule malignancy estimation of incidental clinical nodules.European radiology · 2026Article
- A Vision Toward Risk-Stratified Postoperative Surveillance for Lung Cancer: Harnessing CT and AI.Journal of the American College of Radiology : JACR · 2025Article
- Pulmonary nodules in Denmark: occurrence, resource use, and risk of lung cancer and death.Acta oncologica (Stockholm, Sweden) · 2025Article
- Preclinical Evaluation of Novel SGLT2-Targeted Near-Infrared Optical Imaging Agent for Early-Stage Pulmonary Adenocarcinoma.Molecular imaging and biology · 2025Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo study trends in the incidence of reported pulmonary nodules and stage I lung cancer in chest CT.
methodsWe analyzed the trends in the incidence of detected pulmonary nodules and stage I lung cancer in chest CT scans in the period between 2008 and 2019. Imaging metadata and radiology reports from all chest CT studies were collected from two large Dutch hospitals. A natural language processing algorithm was developed to identify studies with any reported pulmonary nodule.
resultsBetween 2008 and 2019, a total of 74,803 patients underwent 166,688 chest CT examinations at both hospitals combined. During this period, the annual number of chest CT scans increased from 9955 scans in 6845 patients in 2008 to 20,476 scans in 13,286 patients in 2019. The proportion of patients in whom nodules (old or new) were reported increased from 38% (2595/6845) in 2008 to 50% (6654/13,286) in 2019. The proportion of patients in whom significant new nodules (≥ 5 mm) were reported increased from 9% (608/6954) in 2010 to 17% (1660/9883) in 2017. The number of patients with new nodules and corresponding stage I lung cancer diagnosis tripled and their proportion doubled, from 0.4% (26/6954) in 2010 to 0.8% (78/9883) in 2017.
conclusionThe identification of incidental pulmonary nodules in chest CT has steadily increased over the past decade and has been accompanied by more stage I lung cancer diagnoses. CLINICAL RELEVANCE STATEMENT: These findings stress the importance of identifying and efficiently managing incidental pulmonary nodules in routine clinical practice. KEY POINTS: • The number of patients who underwent chest CT examinations substantially increased over the past decade, as did the number of patients in whom pulmonary nodules were identified. • The increased use of chest CT and more frequently identified pulmonary nodules were associated with more stage I lung cancer diagnoses.
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