Evidence map›Paper›PMID 37338407›Full record

ArticleJournal of virology2023

Liver X Receptor-Inducible Host E3 Ligase IDOL Targets a Human Cytomegalovirus Reactivation Determinant.

Luwanika Mlera, Donna Collins-McMillen, Sebastian Zeltzer, Jason C Buehler, Melissa Moy, Kristen Zarrella, Katie Caviness, Louis Cicchini, David J Tafoya, Felicia Goodrum

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Viral and host network analysis of the human cytomegalovirus transcriptome in latency.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Luwanika MleraDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.
Donna Collins-McMillenDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.
Sebastian ZeltzerDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.
Jason C BuehlerDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.
Melissa MoyGraduate Interdisciplinary Program in Cancer Biology, University of Arizona, Tucson, Arizona, USA.
Kristen ZarrellaDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.
Katie CavinessDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.
Louis CicchiniBIO5 Institute, University of Arizona, Tucson, Arizona, USA.
David J TafoyaDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.
Felicia GoodrumDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-6646-7290
University of Arizona · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic CellsR01AI079059 · NIAID · UNIVERSITY OF ARIZONA · PI GOODRUM, FELICIA D · 2008 to 2018
$4.4M
Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic CellsR37AI079059 · NIAID · UNIVERSITY OF ARIZONA · PI Felicia D Goodrum · 2019 to 2026
$3.3M
CMV Control of Host Membrane TraffickingR01AI131598 · NIAID · UNIVERSITY OF ARIZONA · PI GOODRUM, FELICIA D, WILSON, JEAN M · 2018 to 2022
$2.1M
Infection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training ProgramT32AG058503 · NIA · UNIVERSITY OF ARIZONA · PI Kristian Paul Doyle, JANKO Z. NIKOLICH · 2019 to 2026
$1.9M
NCI NIH HHS P30 CA023074NIAID NIH HHS R01 AI079059NIAID NIH HHS R01 AI131598NIAID NIH HHS R37 AI079059NIA NIH HHS T32 AG058503
6 · The paper itself

Abstract

Liver X receptor (LXR) signaling broadly restricts virus replication; however, the mechanisms of restriction are poorly defined. Here, we demonstrate that the cellular E3 ligase LXR-inducible degrader of low-density lipoprotein receptor (IDOL) targets the human cytomegalovirus (HMCV) UL136p33 protein for turnover.

Indexed as

CytomegalovirusUbiquitin-Protein LigasesHumansLipoproteins, LDLLiver X ReceptorsViral ProteinsVirus LatencyLipoproteins, LDLLiver X ReceptorsUbiquitin-Protein LigasesUL136 protein, human herpesvirus 5Viral ProteinscholesterolcytomegalovirusherpesvirusIDOLliver X receptor signalingLXRUL136

Identifiers

PMID37338407
PMCPMC10373547
OpenAlexW4381248219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.