Evidence map›Paper›PMID 37338162›Full record

ArticleACS chemical biology2023

Synthesis of Gamma-Butyrolactone Hormones Enables Understanding of Natural Product Induction.

Lauren E Wilbanks, Haylie E Hennigan, Christina D Martinez-Brokaw, Hani Lakkis, Sarah Thormann, Alyssa S Eggly, Grace Buechel, Elizabeth I Parkinson

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. DAP-seq Reveals Cluster-Situated Regulator Control of NumerousbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Small molecule inducers of actinobacteria natural product biosynthesis.Journal of industrial microbiology & biotechnology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lauren E WilbanksDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Haylie E HenniganDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Christina D Martinez-BrokawDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Hani LakkisDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Sarah ThormannDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Alyssa S EgglyDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Grace BuechelDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Elizabeth I ParkinsonDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-3665-5522
Purdue University West Lafayette · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Gamma Butyrolactones as Biosynthetic Gene Cluster InducersF32GM140569 · NIGMS · PURDUE UNIVERSITY · PI MARTINEZ, CHRISTINA · 2021 to 2021
$57k
NCI NIH HHS P30 CA023168NIGMS NIH HHS F32 GM140569
6 · The paper itself

Abstract

Bacteria produce natural products (NPs) via biosynthetic gene clusters. Unfortunately, many biosynthetic gene clusters are silent under traditional laboratory conditions. To access novel NPs, a better understanding of their regulation is needed. γ-Butyrolactones, including the A-factor and

Indexed as

StreptomycesStreptomyces coelicolor4-ButyrolactoneBacterial ProteinsGene Expression Regulation, BacterialHormones4-ButyrolactoneBacterial ProteinsHormones

Identifiers

PMID37338162
PMCPMC10368014
OpenAlexW4381244787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.