Evidence map›Paper›PMID 37338096›Full record

ArticleJournal of proteome research2023

Cerebrospinal Fluid Protein Biomarker Discovery in CLN3.

An N Dang Do, David E Sleat, Kiersten Campbell, Nicholas L Johnson, Haiyan Zheng, Christopher A Wassif, Ryan K Dale, Forbes D Porter

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Recent Advances in Human Cerebrospinal Fluid Proteomics.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

An N Dang DoUnit on Cellular Stress in Development and Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0002-4171-0493
David E SleatCenter for Advanced Biotechnology and Medicine, Rutgers Biomedical Health Sciences, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-5159-9928
Kiersten CampbellBioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, United States.
Nicholas L JohnsonBioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, United States.
Haiyan ZhengCenter for Advanced Biotechnology and Medicine, Rutgers Biomedical Health Sciences, Piscataway, New Jersey 08854, United States.
Christopher A WassifSection on Molecular Dysmorphology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, United States.
Ryan K DaleBioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, United States.
Forbes D PorterSection on Molecular Dysmorphology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, United States.
National Institutes of Health · USRutgers, The State University of New Jersey · US

Funding

NICHD Bioinformatics and Scientific Programming CoreZICHD008986 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI DALE, RYAN · 2019 to 2025
$17.4M
Clinical Investigations of Inborn Errors of MetabolismZIAHD008989 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PORTER, FORBES · 2020 to 2025
$5.1M
Research Investigations of Cellular Stress in Development and DiseasesZIAHD009001 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI DANG DO, AN · 2022 to 2025
$4.9M
An Orbitrap Tribrid mass spectrometer and nanoflow LC system to upgrade the proteomics facility at Rutgers-New Brunswick and Robert Wood Johnson Medical SchoolS10OD025140 · OD · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI LOBEL, PETER · 2019 to 2019
$921k
Intramural NIH HHS ZIA HD008989Intramural NIH HHS ZIA HD009001Intramural NIH HHS ZIC HD008986NIH HHS S10 OD025140
6 · The paper itself

Abstract

Syndromic CLN3-Batten is a fatal, pediatric, neurodegenerative disease caused by variants in

Indexed as

Neurodegenerative DiseasesNeuronal Ceroid-LipofuscinosesCerebrospinal Fluid ProteinsChildHumansMembrane GlycoproteinsMolecular ChaperonesProteomicsCerebrospinal Fluid ProteinsMembrane GlycoproteinsMolecular ChaperonesBattenCD302CHIT1ISLR2JNCLmass spectrometryNEFLNELL1protein biomarkersproximal extension assay

Identifiers

PMID37338096
PMCPMC11095826
OpenAlexW4381309385

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.