Evidence map›Paper›PMID 37338087›Full record

ArticleOral diseases2024

Evaluation of the mandibular condylar bone microarchitecture in people living with HIV.

Sunil Wadhwa, Michael Levit, Satoko Matsumura, Shin Jung Hsieh, Karolina Kister, Cleber Silva, Jayesh Shah, Anyelina Cantos, Bruno Bohn, Ryan T Demmer and 1 more

Open access · greenAbstract read
In one paragraph

Article in Oral diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sunil WadhwaDivision of Orthodontics, Columbia University College of Dental Medicine, New York, New York, USA.ORCID 0000-0001-5743-9231
Michael LevitDivision of Orthodontics, Columbia University College of Dental Medicine, New York, New York, USA.
Satoko MatsumuraDivision of Oral and Maxillofacial Radiology, Columbia University College of Dental Medicine, New York, New York, USA.ORCID 0000-0003-2774-3560
Shin Jung HsiehDivision of Orthodontics, Columbia University College of Dental Medicine, New York, New York, USA.
Karolina KisterDivision of Orthodontics, Columbia University College of Dental Medicine, New York, New York, USA.ORCID 0000-0001-7481-0418
Cleber SilvaDivision of Oral and Maxillofacial Radiology, Columbia University College of Dental Medicine, New York, New York, USA.ORCID 0009-0009-2305-737X
Jayesh ShahDivision of Infectious Diseases, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Anyelina CantosDivision of Infectious Diseases, Columbia University College of Physicians and Surgeons, New York, New York, USA.ORCID 0000-0002-2828-0281
Bruno BohnSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-8961-6968
Ryan T DemmerSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-3429-0379
Michael T YinDivision of Infectious Diseases, Columbia University College of Physicians and Surgeons, New York, New York, USA.ORCID 0000-0002-9346-9056
Columbia University · USNew York University · USUniversity of Minnesota · US

Funding

Oral immune activation and alveolar bone loss in HIV-infected postmenopausal womenR01DE026924 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WADHWA, SUNIL, YIN, MICHAEL T · 2017 to 2021
$2.3M
Mentoring Research in Non-infectious Complications of HIVK24AI155230 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YIN, MICHAEL T · 2021 to 2025
$940k
NIAID NIH HHS K24 AI155230NIDCR NIH HHS R01 DE026924
6 · The paper itself

Abstract

objectivesPeople living with HIV (PLWH) have been shown to have lower bone density at the spine, hip, and radius. However, whether a similar bone phenotype is seen in craniofacial bones is not known. The goal of this study was to evaluate the bone microarchitecture of the mandibular condyle in PLWH.

methodsWe recruited 212 participants, which included 88 HIV-negative participants and 124 PLWH on combination antiretroviral therapy with virological suppression from a single academic center. Each participant filled out a validated temporomandibular disorder (TMD) pain screening questionnaire and had cone beam computed tomography (CBCT) of their mandibular condyles. Qualitative radiographic evidence of temporomandibular joint disorders-osteoarthritis (TMJD-OA) assessment and quantitative microarchitecture analysis of their mandibular condylar bones were conducted.

resultsThere was no statistically significant difference in either self-reported TMD or in radiographic evidence of TMJD-OA in PLWH compared with HIV-negative controls. Linear regression analysis revealed that positive HIV status remained significantly associated with increased trabecular thickness, decreased cortical porosity, and increased cortical bone volume fraction after adjusting for race, diabetes, sex, and age.

conclusionPLWH have increased mandibular condylar trabecular bone thickness and cortical bone volume fraction compared with HIV-negative controls.

Indexed as

Cone-Beam Computed TomographyHIV InfectionsMandibular CondyleAdultBone DensityCancellous BoneCase-Control StudiesCortical BoneFemaleHumansMaleMiddle AgedOsteoarthritisTemporomandibular Joint Disorderscone beam computed tomographycortical boneHIVmandibular condylequantitative microstructure evaluationtemporomandibular disorderstrabecular bone

Identifiers

PMID37338087
PMCPMC10730762
OpenAlexW4381309668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.