ArticleAnnals of surgical treatment and research2023
Effect of prehabilitation on patients with frailty undergoing colorectal cancer surgery: a systematic review and meta-analysis.
Article in Annals of surgical treatment and research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Prehabilitation in Frail Patients Undergoing Cancer Surgery: A Systematic Review and Meta-analysis.Annals of surgical oncology · 2025Pooled it
- Effectiveness of Prehabilitation Modalities on Postoperative Outcomes Following Colorectal Cancer Surgery: A Systematic Review of Randomised Controlled Trials.Annals of surgical oncology · 2024Pooled it
- Frailty worsens long-term survival in patients with colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Pre-Operative Resistance Training and Amino Acid Supplementation in Frail Patients With Gastrointestinal Cancer: A Randomized Clinical Trial.Geriatrics & gerontology international · 2025Trial
- Optimizing Physical Fitness Before Colorectal Cancer Surgery (CANOPTIPHYS): The Effect of Preoperative Exercise on Pre- and Postoperative Physical Fitness in Older people - A Randomized Controlled Trial.Journal of primary care & community healthTrial
- Prehabilitation Prior to Colorectal Cancer Surgery: Impact and Implementation.Journal of surgical oncology · 2026Article
- Review
- Long-Term Functional Outcomes After Prehabilitation in Frail Older Adults Undergoing Colorectal Cancer Surgery: A One-Year Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Prehabilitation and postoperative outcomes in colorectal surgery: an umbrella review.Journal of anesthesia, analgesia and critical care · 2026Review
- WWP2 ubiquitin ligase promotes colorectal cancer progression by targeting p53 for degradation: an experimental study.Annals of surgical treatment and research · 2026Article
- Identifying Patients with Colorectal Cancer Likely to Benefit from a Trimodal Prehabilitation Prior to Surgery.Nutrients · 2026Article
- Impact of diabetes mellitus and grip strength on postoperative outcomes in older patients undergoing cancer surgery: A single-center retrospective cohort study.Journal of diabetes investigation · 2026Article
- Individual multimodal prehabilitation in high-risk patients undergoing major abdominal surgery following neoadjuvant treatment - a feasibility study.Langenbeck's archives of surgery · 2025Article
- Perspectives on prehabilitation for older adults with cancer: A report from the International Society of Geriatric Oncology (SIOG) rehabilitation group.Journal of geriatric oncology · 2025Article
- The inequalities and challenges of prehabilitation before cancer surgery: a narrative review.Anaesthesia · 2025Review
- Training gut and body: physical activity, diet, ASA and microbiota influence the outcome in gastrointestinal cancer survivors.Frontiers in nutrition · 2025Review
- Higher hospital frailty risk score is predictive of 90-day readmission after minimally invasive colorectal cancer surgery: a national readmission database analysis.American journal of cancer research · 2025Article
- Prehabilitation in Frail Octogenarian and Nonagenarian Patients in Colorectal Cancer Surgery: Short- and Medium-Term Outcomes.Journal of clinical medicine · 2024Article
- Varying clinical relevance of sarcopenia and myosteatosis according to age among patients with postoperative colorectal cancer.The journal of nutrition, health & aging · 2024Article
- Sarcopenia diagnosis in patients with colorectal cancer: a review of computed tomography-based assessments and emerging ways to enhance practicality.Annals of surgical treatment and research · 2024Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The effect of prehabilitation in patients with frailty undergoing colorectal cancer surgery remains controversial. This meta-analysis aimed to assess the impact of prehabilitation before colorectal surgery on the functional outcomes and postoperative complications in patients with frailty undergoing colorectal cancer surgery. Methods: PubMed, EMBASE, Cochrane Library, and Scopus databases were searched for articles published up to November 9, 2022. We included randomized and non-randomized trials in which the effects of prehabilitation in patients with frailty undergoing colorectal cancer surgery were investigated against a control group. Data extracted for our meta-analysis included the 6-minute walk test (6MWT), postoperative incidence of complications (Clavien-Dindo classification ≥IIIa), comprehensive complication index (CCI), and length of stay (LOS) in the hospital. Results: Compared with the control group, we found a significant improvement in the incidence of postoperative complications and shorter LOS in the hospital in the prehabilitation group. However, the 6MWT and CCI results showed no significant differences between the 2 groups. Conclusion: Prehabilitation in patients with frailty who underwent colorectal cancer surgery improved the incidence of postoperative complications and LOS in the hospital. Hence, clinicians should consider conducting or recommending prehabilitation exercises prior to colorectal cancer surgery in patients with frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.