ArticleBMC biology2023
The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes.
Article in BMC biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 26 citations in OpenAlex.
- A sponge homolog of BRMS1 reveals ancient origin of metastasis-suppressing functions.BMC biology · 2026Article
- Chromosome-level genome assembly of the sponge Halisarca dujardinii.Scientific data · 2026Article
- Innovations in Silicon Transport Shaped the Rise of Biosilicification and Skeletal Evolution in Sponges.Molecular biology and evolution · 2026Article
- Independent origins of spicules reconcile paleontological and molecular evidence of sponge evolutionary history.Science advances · 2026Article
- New insights into the microbiome of the deep-sea spongeMicrobial genomics · 2026Article
- First draft genome assembly of sponge Halisarca dujardinii reveals key components of basement membrane and broad repertoire of aggregation factors.Scientific reports · 2025Article
- G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa.eLife · 2025Article
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- Covering All Bases: A Universal Metazoan UCE Probe Set to Democratize Phylogenomics.Genome biology and evolution · 2025Article
- Myxozoan parasite genomes assembled from contaminated host data reveal extensive gene order conservation and rapid sequence evolution.G3 (Bethesda, Md.) · 2025Article
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- The genome of the simultaneously hermaphroditic snail Lymnaea stagnalis reveals an evolutionary expansion of FMRFamide-like receptors.Scientific reports · 2024Article
- The origin and evolution of Wnt signalling.Nature reviews. Genetics · 2024Review
- Silactins and Structural Diversity of Biosilica in Sponges.Biomimetics (Basel, Switzerland) · 2024Article
- Highly conserved and extremely evolvable: BMP signalling in secondary axis patterning of Cnidaria and Bilateria.Development genes and evolution · 2024Review
- Silica-associated proteins from hexactinellid sponges support an alternative evolutionary scenario for biomineralization in Porifera.Nature communications · 2024Article
- Whole genome sequence of the deep-sea sponge Geodia barretti (Metazoa, Porifera, Demospongiae).G3 (Bethesda, Md.) · 2023Article
- Article
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15 authors at 3 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExplaining the emergence of the hallmarks of bilaterians is a central focus of evolutionary developmental biology-evodevo-and evolutionary genomics. For this purpose, we must both expand and also refine our knowledge of non-bilaterian genomes, especially by studying early branching animals, in particular those in the metazoan phylum Porifera.
resultsWe present a comprehensive analysis of the first whole genome of a glass sponge, Oopsacas minuta, a member of the Hexactinellida. Studying this class of sponge is evolutionary relevant because it differs from the three other Porifera classes in terms of development, tissue organization, ecology, and physiology. Although O. minuta does not exhibit drastic body simplifications, its genome is among the smallest of animal genomes sequenced so far, and surprisingly lacks several metazoan core genes (including Wnt and several key transcription factors). Our study also provides the complete genome of a symbiotic Archaea dominating the associated microbial community: a new Thaumarchaeota species.
conclusionsThe genome of the glass sponge O. minuta differs from all other available sponge genomes by its compactness and smaller number of encoded proteins. The unexpected loss of numerous genes previously considered ancestral and pivotal for metazoan morphogenetic processes most likely reflects the peculiar syncytial tissue organization in this group. Our work further documents the importance of convergence during animal evolution, with multiple convergent evolution of septate-like junctions, electrical-signaling and multiciliated cells in metazoans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.