ArticleBMC geriatrics2023
Association between medication literacy and medication adherence and the mediating effect of self-efficacy in older people with multimorbidity.
Article in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Pooled it
- Unravelling the role of health literacy among individuals with multimorbidity: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Exploring medication self-management in polypharmacy: a qualitative systematic review of patients and healthcare providers perspectives.Frontiers in pharmacology · 2024Pooled it
- Effectiveness of a Behavior Change Wheel-Informed WeChat-Based Messaging Intervention to Improve Medication Adherence After Percutaneous Coronary Intervention: 12-Week Quasi-Experimental Study.Journal of medical Internet research · 2026Article
- Health literacy and therapeutic adherence: a network and mediation analysis in dyslipidemic outpatients.Internal and emergency medicine · 2026Article
- Health Literacy and Chronic Disease Self-Efficacy Among Older Adults with Multimorbidity: Evidence from Low-Resource Context.Healthcare (Basel, Switzerland) · 2026Article
- Assessment of Medication Adherence Among Heart Failure Patients in an Ambulatory Care Setting: A Prospective Observational Study.Journal of clinical medicine · 2026Article
- Psychosocial factors associated with medication adherence among older adults with chronic diseases: an ITHBC-informed cross-sectional study.Scientific reports · 2026Article
- The mediating role of self-efficacy in health literacy and chronic disease self-management in older individuals.BMC geriatrics · 2026Article
- Development of a questionnaire to assess the medication literacy of patients receiving oral anticancer drugs.Scientific reports · 2026Article
- Smart Technology-Assisted Patient-Centered Management in Venous Thromboembolism: Pilot Study on Anticoagulation Adherence.JMIR formative research · 2026Article
- Medication adherence among geriatric patients with chronic diseases in rural China: a social ecological model perspective.BMC geriatrics · 2026Article
- The impact of stigma on medication adherence among patients with multimorbidity: mediation analysis of medication literacy.Frontiers in public health · 2026Article
- A Network Analysis of Medication Literacy and Associated Psychological Factors in Patients with Coronary Heart Disease and Diabetes.Patient preference and adherence · 2026Article
- Family Function and Medication Safety Behaviors in Older Adults with Cancer: A Serial Mediation Analysis.Patient preference and adherence · 2026Article
- Association of Chronic Pain Severity and NSAID Use with Self-Reported Kidney Risk Indicators: A 1-Year Cohort Study.Juntendo medical journal · 2026Article
- Medication Adherence Patterns for Patients with Atrial Fibrillation: A Mixed Methods Study to Understand Patient and Clinician Perspectives.Patient preference and adherence · 2026Article
- The Mediating Roles of Self-Efficacy, Resilience, and Social Support in the Relationship Between Clinical Factors and Adaptation to Chronic Disease.Journal of multidisciplinary healthcare · 2026Article
- Assessment of Factors Associated with Treatment Adherence Among Elderly Patients with Multimorbid Type 2 Diabetes Mellitus Using Lasso-Logistic Regression.Patient preference and adherence · 2026Article
- Psychosocial predictors of non-adherence to antihypertensive medication among Korean adults: A nationwide cross-sectional study.PloS one · 2026Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundMultimorbidity has a significant impact on public health and primary care. Medication adherence is recognized as the most effective measure for managing and preventing multimorbidity. Studies have shown that medication literacy has a positive effect on medication adherence in patients with multimorbidity. However, limited knowledge exists regarding the underlying mechanisms of this relationship in older adults with multimorbidity. Therefore, the aim of this study was to investigate the mediating role of self-efficacy in the association between medication literacy and medication adherence in this population.
methodsThis study employed a cross-sectional design and convenience sampling method to survey older patients with multimorbidity in six communities in Zhengzhou, China, from July 12, 2021, to December 15, 2021. Participants were assessed using a demographic questionnaire, the Chinese Version of the Medication Literacy Scale (C-MLS), the Self-Efficacy for Appropriate Medication Use Scale (SEAMS), and the Chinese Version of the Morisky Medication Adherence Scale-8 (C-MMAS-8). Data were analyzed using descriptive statistics, t-tests, one-way analysis of variance, Pearson correlation analysis, and mediation analysis.
resultsA total of 350 elderly patients met the inclusion criteria, and 328 valid questionnaires were collected. The mean age of the participants was 74.90 ± 7.37 years, with a slightly higher proportion of males (55.8%) than females (44.2%). The mean score for medication adherence was 4.85 ± 1.57, indicating poor medication adherence among the participants. Medication adherence scores varied significantly among participants of different ages, education levels, employment statuses and kinds of medication (p < 0.01). Scores for medication literacy and self-efficacy showed a significant positive correlation with medication adherence scores (all p < 0.001). The standardized coefficient for the total effect and direct effect of medication literacy on medication adherence was 0.268 (95% CI: 0.201, 0.335) and 0.187 (95% CI: 0.123, 0.252), respectively. After introducing self-efficacy into the model, the standardized coefficient for the indirect effect was 0.081 (95% CI: 0.049, 0.120), indicating that self-efficacy partially mediated the relationship between medication literacy and medication adherence, accounting for 30.22% of the total effect.
conclusionThis study might suggest that medication literacy indirectly affected medication adherence in older people with multimorbidity through self-efficacy. Health care providers should be aware of the importance of improving medication literacy and implement strategies aimed at increasing self-efficacy to achieve the goal of improving medication adherence in older adults with multimorbidity.
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