Evidence map›Paper›PMID 37337107›Full record

ArticleNature genetics2023

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy.

Krzysztof Kiryluk, Elena Sanchez-Rodriguez, Xu-Jie Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasa, Jun Y Zhang, Olivia Balderes and 178 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Identification ofFrontiers in immunology · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Genetic Determinants of Steroid Responsiveness in IgA Nephropathy.Journal of the American Society of Nephrology : JASN · 2026
    Trial
  6. Trial
  7. Trial
  8. Article
  9. APRIL: spring forward also for IgA vasculitis nephritis in children.Pediatric nephrology (Berlin, Germany) · 2026
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. IgA nephropathy management: what does the future hold?Kidney international supplements · 2026
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Atlas of glomerular disease-specific genetic effects on blood transcriptome.medRxiv : the preprint server for health sciences · 2026
    Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

188 authors.

Krzysztof KirylukDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA. kk473@columbia.edu.ORCID 0000-0002-5047-6715
Elena Sanchez-Rodriguez *Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.ORCID 0000-0002-7041-5485
Xu-Jie Zhou *Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
Francesca ZanoniDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Lili LiuDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.ORCID 0000-0002-2622-9669
Nikol MladkovaDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Atlas KhanDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.ORCID 0000-0002-6651-2725
Maddalena MarasaDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Jun Y ZhangDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.ORCID 0000-0003-4996-8699
Olivia BalderesDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Simone Sanna-CherchiDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.ORCID 0000-0002-6185-948X
Andrew S BombackDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.ORCID 0000-0001-5449-1667
Pietro A CanettaDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.ORCID 0000-0003-1130-5486
Gerald B AppelDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Jai RadhakrishnanDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.
Hernan TrimarchiNephrology Service, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.
Ben SprangersDepartment of Microbiology and Immunology, Laboratory of Molecular Immunology, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1314-9675
Daniel C CattranDepartment of Nephrology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada.
Heather ReichDepartment of Nephrology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada.
York PeiDepartment of Nephrology, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada.
Pietro RavaniDivision of Nephrology, Department of Internal Medicine, University of Calgary, Calgary, Alberta, Canada.
Kresimir GalesicZagreb Medical School, Zagreb, Croatia.
Dita Maixnerova1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic.
Vladimir Tesar1st Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic.ORCID 0000-0001-6982-0689
Benedicte StengelCentre for Research in Epidemiology and Population Health (CESP), Paris-Saclay University, Versailles Saint Quentin University, INSERM Clinical Epidemiology Team, Villejuif, France.
Marie MetzgerCentre for Research in Epidemiology and Population Health (CESP), Paris-Saclay University, Versailles Saint Quentin University, INSERM Clinical Epidemiology Team, Villejuif, France.
Guillaume CanaudUniversité de Paris, Hôpital Necker-Enfants Malades, Paris, France.
Nicolas MaillardNephrology, Dialysis, and Renal Transplantation Department, University North Hospital, Saint Etienne, France.
Francois BerthouxNephrology, Dialysis, and Renal Transplantation Department, University North Hospital, Saint Etienne, France.
Laureline BerthelotCRTI, Nantes University, Nantes, France.ORCID 0000-0002-9306-9247
Evangeline PilleboutCenter for Research on Inflammation, University of Paris, INSERM and CNRS, Paris, France.
Renato MonteiroCenter for Research on Inflammation, University of Paris, INSERM and CNRS, Paris, France.
Raoul NelsonDivision of Pediatric Nephrology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Robert J WyattDivision of Pediatric Nephrology, University of Tennessee Health Sciences Center, Memphis, TN, USA.
William SmoyerDivision of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, USA.
John MahanDivision of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, USA.
Al-Akash SamharDivision of Pediatric Nephrology, Driscoll Children's Hospital, Corpus Christi, TX, USA.
Guillermo HidalgoDivision of Pediatric Nephrology, Department of Pediatrics, HMH Hackensack University Medical Center, Hackensack, NJ, USA.
Alejandro QuirogaDivision of Pediatric Nephrology, Helen DeVos Children's Hospital, Grand Rapids, MI, USA.
Patricia WengDivision of Pediatric Nephrology, Mattel Children's Hospital, Los Angeles, CA, USA.
Raji SreedharanDivision of Pediatric Nephrology, Medical College of Wisconsin, Milwaukee, WI, USA.
David SelewskiDivision of Pediatric Nephrology, Mott Children's Hospital, Ann Arbor, MI, USA.
Keefe DavisDivision of Pediatric Nephrology, Department of Pediatrics, The Medical University of South Carolina (MUSC), Charleston, SC, USA.
Mahmoud KallashDivision of Pediatric Nephrology, SUNY Buffalo, Buffalo, NY, USA.
Tetyana L VasylyevaDivision of Pediatric Nephrology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0003-3236-985X
Michelle RheaultDivision of Pediatric Nephrology, University of Minnesota, Minneapolis, MN, USA.
Aftab ChishtiDivision of Pediatric Nephrology, University of Kentucky, Lexington, KY, USA.
Daniel RanchDivision of Pediatric Nephrology, Department of Pediatrics, University of Kentucky, Lexington, KY, USA.ORCID 0000-0002-2702-0218
Scott E WenderferDivision of Pediatric Nephrology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-8991-8277
Dmitry SamsonovDivision of Pediatric Nephrology, Boston Children's Hospital, Boston, MA, USA.
Donna J ClaesDivision of Pediatric Nephrology, Department of Pediatrics, New York Medical College, New York City, NY, USA.
Oleh AkchurinDivision of Pediatric Nephrology, Department of Pediatrics, Weill Cornell Medical College, New York City, NY, USA.ORCID 0000-0002-3745-5418
Dimitrios GoumenosThe Aristotle University of Thessaloniki, Thessaloniki, Greece.
Maria StangouThe Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID 0000-0003-2496-9863
Judit Nagy2nd Department of Internal Medicine, Nephrological and Diabetological Center, University of Pécs, Pécs, Hungary.
Tibor Kovacs2nd Department of Internal Medicine, Nephrological and Diabetological Center, University of Pécs, Pécs, Hungary.
Enrico FiaccadoriDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Antonio AmorosoDepartment of Medical Sciences, University of Turin, Turin, Italy.ORCID 0000-0002-9437-9407
Cristina BarlassinaRenal Division, Dipartimento di Medicina, Chirurgia e Odontoiatria, San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.
Daniele CusiRenal Division, Dipartimento di Medicina, Chirurgia e Odontoiatria, San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.
Lucia Del VecchioDepartment of Nephrology and Dialysis, ASST Lariana, Como, Italy.
Giovanni Giorgio BattagliaUnità Operativa di Nefrologia e Dialisi, Ospedale di Acireale, Acireale, Italy.
Monica BodriaUniversity of Messina, Messina, Italy.
Emanuela BoerDivision of Nephrology and Dialysis, Gorizia Hospital, Gorizia, Italy.
Luisa BonoNephrology and Dialysis, A.R.N.A.S. Civico and Benfratelli, Palermo, Italy.
Giuliano BoscuttiNephrology, Dialysis and Renal Transplant Unit, S. Maria della Misericordia Hospital, ASUFC, Udine, Italy.
Gianluca CaridiDivision of Nephrology, Dialysis and Transplantation, IRCCS Giannina Gaslini Institute, Genova, Italy.ORCID 0000-0001-6700-3001
Francesca LuganiDivision of Nephrology, Dialysis and Transplantation, IRCCS Giannina Gaslini Institute, Genova, Italy.
GianMarco GhiggeriDivision of Nephrology, Dialysis and Transplantation, IRCCS Giannina Gaslini Institute, Genova, Italy.ORCID 0000-0003-3659-9062
Rosanna CoppoRegina Margherita Children's Hospital, Torino, Italy.
Licia PeruzziRegina Margherita Children's Hospital, Torino, Italy.ORCID 0000-0002-5704-3867
Vittoria EspositoICS Maugeri SpA, University of Pavia, Pavia, Italy.
Ciro EspositoICS Maugeri SpA, University of Pavia, Pavia, Italy.
Sandro FeriozziBelcolle Hospital, Viterbo, Italy.
Rosaria PolciBelcolle Hospital, Viterbo, Italy.
Giovanni FrascaDivision of Nephrology, Dialysis and Renal Transplantation, Riuniti Hospital, Ancona, Italy.
Marco GallianiSandro Pertini Hospital, Rome, Italy.
Maurizio GarozzoUnità Operativa di Nefrologia e Dialisi, Ospedale di Acireale, Acireale, Italy.
Adele MitrottiNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.
Loreto GesualdoNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.
Simona GranataRenal Unit, Department of Medicine, University of Verona, Verona, Italy.
Gianluigi ZazaRenal Unit, Department of Medicine, University of Verona, Verona, Italy.ORCID 0000-0002-6004-6196
Francesco LondrinoS. Andrea Hospital, La Spezia, Italy.
Riccardo MagistroniDepartment of Surgical, Medical, Dental, Oncologic and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0002-3319-0248
Isabella PisaniDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Andrea MagnanoDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Carmelita MarcantoniNephrology Division, San Marco Hospital, Catania, Italy.
Piergiorgio MessaNephrology Dialysis and Kidney Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.
Renzo MignaniAzienda Unità Sanitaria Locale Rimini, Rimini, Italy.
Antonello PaniDepartment of Nephrology and Dialysis, G. Brotzu Hospital, Cagliari, Italy.
Claudio PonticelliNephrology and Dialysis, Ospedale Maggiore, Milan, Italy.
Dario RoccatelloNephrology and Dialysis Unit, G. Bosco Hub Hospital (ERK-net Member) and University of Torino, Torino, Italy.ORCID 0000-0002-4419-6813
Maurizio SalvadoriDivision of Nephrology and Renal Transplantation, Carreggi Hospital, Florence, Italy.
Erica SalviRenal Division, DMCO (Dipartimento di Medicina, Chirurgia e Odontoiatria), San Paolo Hospital, School of Medicine, University of Milan, Milan, Italy.
Domenico SantoroUnit of Nephrology and Dialysis, AOU G Martino, University of Messina, Messina, Italy.
Guido GembilloUnit of Nephrology and Dialysis, AOU G Martino, University of Messina, Messina, Italy.
Silvana SavoldiUnit of Nephrology and Dialysis, ASL TO4-Consultorio Cirié, Turin, Italy.
Donatella SpottiSan Raffaele Hospital, Milan, Italy.
Pasquale ZamboliNephroCare Italy, Naples, Italy.
Claudia IzziDepartment of Medical and Surgical Specialties and Nephrology Unit, University of Brescia-ASST Spedali Civili, Brescia, Italy.
Federico AlbericiDepartment of Medical and Surgical Specialties and Nephrology Unit, University of Brescia-ASST Spedali Civili, Brescia, Italy.
Elisa DelbarbaDepartment of Medical and Surgical Specialties and Nephrology Unit, University of Brescia-ASST Spedali Civili, Brescia, Italy.
Michał FlorczakDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Natalia KrataDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0003-0564-0819
Krzysztof MuchaDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0002-6613-7638
Leszek PączekDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Stanisław NiemczykDepartment of Internal Disease, Nephrology and Dialysotherapy, Military Institute of Medicine, Warsaw, Poland.
Barbara MoszczukDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Malgorzata Pańczyk-TomaszewskaDepartment of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Malgorzata Mizerska-WasiakDepartment of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Agnieszka Perkowska-PtasińskaDepartment of Pathology, Medical University of Warsaw, Warsaw, Poland.
Teresa BączkowskaDepartment of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Magdalena DurlikDepartment of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Krzysztof PawlaczykDepartment of Nephrology, Transplantology and Internal Medicine, Poznan Medical University, Poznan, Poland.
Przemyslaw SikoraDepartment of Pediatric Nephrology, Medical University of Lublin, Lublin, Poland.
Marcin ZaniewDepartment of Pediatrics, University of Zielona Góra, Zielona Góra, Poland.
Dorota KaminskaClinical Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
Magdalena KrajewskaClinical Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.ORCID 0000-0002-2632-2409
Izabella Kuzmiuk-GlembinDepartment of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.ORCID 0000-0002-0625-148X
Zbigniew HeleniakDepartment of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.
Barbara Bullo-PionteckaDepartment of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.
Tomasz LiberekDepartment of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.
Alicja Dębska-SlizienDepartment of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.
Tomasz Hryszko2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Bialystok, Poland.ORCID 0000-0002-0145-3103
Anna Materna-KirylukDepartment of Genetics, Medical University of Poznan, Poznan, Poland.
Monika MiklaszewskaDepartment of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, Krakow, Poland.
Maria SzczepańskaDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.ORCID 0000-0001-5336-261X
Katarzyna DygaDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
Edyta MachuraDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
Katarzyna Siniewicz-LuzeńczykDepartment of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
Monika Pawlak-BratkowskaDepartment of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
Marcin TkaczykDepartment of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
Dariusz RunowskiDepartment of Nephrology, Kidney Transplantation and Hypertension, Children's Memorial Health Institute, Warsaw, Poland.
Norbert KwellaDepartment of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Dorota DrożdżDepartment of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, Krakow, Poland.
Ireneusz HaburaDepartment of Nephrology, Karol Marcinkowski Hospital, Zielona Góra, Poland.ORCID 0000-0001-6936-5428
Florian KronenbergInstitute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-2229-1120
Larisa PrikhodinaDivision of Inherited and Acquired Kidney Diseases, Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russia.ORCID 0000-0002-0702-4932
David van HeelBarts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-0637-2265
Bertrand FontaineSorbonne University, INSERM, Center of Research in Myology, Institute of Myology, University Hospital Pitie-Salpetriere, Paris, France.
Chris CotsapasDepartments of Neurology and Genetics, Yale University, New Haven, CT, USA.
Cisca WijmengaUniversity of Groningen, Groningen, the Netherlands.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.ORCID 0000-0003-1530-5811
Vito AnneseCBP American Hospital, Dubai, United Arab Emirates.
Peter K GregersenRobert S. Boas Center for Genomics and Human Genetics, Feinstein Institutes for Medical Research, North Shore LIJ Health System, New York City, NY, USA.
Sreeja ParameswaranCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Matthew WeirauchCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-7977-9122
Leah KottyanCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-3979-2220
John B HarleyUS Department of Veterans Affairs Medical Center and Cincinnati Education and Research for Veterans Foundation, Cincinnati, OH, USA.
Hitoshi SuzukiDepartment of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0002-1901-2111
Ichiei NaritaDivision of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.ORCID 0000-0001-7692-3096
Shin GotoDivision of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Hajeong LeeInternal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Dong Ki KimInternal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0002-5195-7852
Yon Su KimBiomedical Science, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jin-Ho ParkDepartment of Family Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, Republic of Korea.ORCID 0000-0002-3942-6813
BeLong ChoDepartment of Family Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, Republic of Korea.
Murim ChoiBiomedical Science, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0002-9195-1455
Ans Van WijkAmsterdam University Medical Centre, VU University Medical Center (VUMC), Amsterdam, the Netherlands.
Ana HuertaHospital Universitario Puerta del Hierro Majadahonda, REDINREN, IISCIII, Madrid, Spain.ORCID 0000-0003-3342-7628
Elisabet ArsMolecular Biology Laboratory and Nephrology Department, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau, Universitat Autònoma de Barcelona, REDINREN, IISCIII, Barcelona, Spain.ORCID 0000-0002-4118-4358
Jose BallarinMolecular Biology Laboratory and Nephrology Department, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau, Universitat Autònoma de Barcelona, REDINREN, IISCIII, Barcelona, Spain.
Sigrid LundbergDepartment of Nephrology, Danderyd University Hospital, and Department of Clinical Sciences, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1224-5200
Bruno VogtDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-1548-6387
Laila-Yasmin ManiDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-4693-7814
Yasar CaliskanDivision of Nephrology, Saint Louis University, Saint Louis, MO, USA.
Jonathan BarrattJohn Walls Renal Unit, University Hospitals of Leicester, Leicester, UK.
Thilini AbeygunaratneSalford Royal Hospital, Salford, UK.
Philip A KalraSalford Royal Hospital, Salford, UK.
Daniel P GaleDepartment of Renal Medicine, University College London, London, UK.ORCID 0000-0002-9170-1579
Ulf PanzerUniversity of Hamburg, Hamburg, Germany.
Thomas RauenDivision of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Jürgen FloegeDivision of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.
Pascal SchlosserInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-8460-0462
Arif B EkiciInstitute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0001-6099-7066
Kai-Uwe EckardtDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-3823-0920
Nan ChenDepartment of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jingyuan XieDepartment of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Richard P LiftonDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID 0000-0002-8532-5087
Eimear E KennyThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Iuliana Ionita-LazaDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York City, NY, USA.ORCID 0000-0002-9001-2026
Anna KöttgenInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-4671-3714
Bruce A JulianDepartments of Microbiology and Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jan NovakDepartments of Microbiology and Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-9211-6670
Francesco ScolariDepartment of Medical and Surgical Specialties and Nephrology Unit, University of Brescia-ASST Spedali Civili, Brescia, Italy.
Hong ZhangRenal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
Ali G GharaviDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA. ag2239@cumc.columbia.edu.ORCID 0000-0003-2801-233X

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
OMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3M
Research Project 3: Role of Posttranslational Protein Modifications in the Pathogenesis of Ebola Virus DiseaseP01AI150585 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BUKREYEV, ALEXANDER · 2021 to 2025
$11.3M
Elucidating IgA Nephropathy through Genetic Studies of IgA1 GlycosylationR01DK082753 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GHARAVI, ALI G, NOVAK, JAN · 2009 to 2024
$8.7M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
HLA GENE COMPLEMENTATION IN PRIMARY SJOGREN'S AND LUPUSR01AI024717 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI KOTTYAN, LEAH CLAIRE, WEIRAUCH, MATTHEW TYSON · 1987 to 2025
$7.8M
Gene Regulation as a Foundation for Autoimmune Disease PreventionU01AI130830 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WEIRAUCH, MATTHEW TYSON · 2017 to 2021
$7.2M
Molecular Basis of Pathogenicity of IgA1-containing Immune ComplexesR01DK078244 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAN NOVAK · 2007 to 2026
$6.0M
Dynamic regulatory network models of human response to influenza virusU01AI150748 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARAZZI, IVAN, MIRALDI, EMILY · 2020 to 2024
$5.8M
Genomics of glomerular diseaseRC2DK116690 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIRYLUK, KRZYSZTOF, KRETZLER, MATTHIAS · 2018 to 2022
$5.0M
Genetics of IgA nephropathy by integrative network-based association studiesR01DK105124 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Krzysztof Kiryluk · 2015 to 2026
$4.8M
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6 · The paper itself

Abstract

IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney-biopsy-diagnosed IgAN cases and 28,751 controls across 17 international cohorts. We defined 30 genome-wide significant risk loci explaining 11% of disease risk. A total of 16 loci were new, including TNFSF4/TNFSF18, REL, CD28, PF4V1, LY86, LYN, ANXA3, TNFSF8/TNFSF15, REEP3, ZMIZ1, OVOL1/RELA, ETS1, IGH, IRF8, TNFRSF13B and FCAR. The risk loci were enriched in gene orthologs causing abnormal IgA levels when genetically manipulated in mice. We also observed a positive genetic correlation between IgAN and serum IgA levels. High polygenic score for IgAN was associated with earlier onset of kidney failure. In a comprehensive functional annotation analysis of candidate causal genes, we observed convergence of biological candidates on a common set of inflammatory signaling pathways and cytokine ligand-receptor pairs, prioritizing potential new drug targets.

Indexed as

Glomerulonephritis, IGAAnimalsGenome-Wide Association StudyImmunoglobulin AMiceImmunoglobulin A

Identifiers

PMID37337107
PMCPMC11824687

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