ArticleNature genetics2023
Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.
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Article in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
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23 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Multi-Trait Genetic Insights Into Schizophrenia Across Ancestries: Genome-Wide Association Meta-Analyses, Machine Learning, and Drug Repurposing Study.Brain and behavior · 2026Pooled it
- DNA methylation signatures of bilateral hippocampal volume, asymmetry and atrophy: a cross-omics analysis in the general population.EBioMedicine · 2026Pooled it
- Cross-ancestry genome-wide association studies of liver function biomarkers uncover pleiotropic variants, systemic disease links and therapeutic targets.Genome medicine · 2026Pooled it
- The genetic architecture of brainstem structures.Nature communications · 2025Pooled it
- Cross-ancestry genome-wide association study identifies new susceptibility genes for preeclampsia.BMC pregnancy and childbirth · 2025Pooled it
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- Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics.Communications medicine · 2025Article
- Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure.Biological psychiatry global open science · 2025Article
- Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants.medRxiv : the preprint server for health sciences · 2025Article
- How growing up without siblings affects the adult brain and behaviour in the CHIMGEN cohort.Nature human behaviour · 2025Article
- Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes.Nature genetics · 2025Article
- Genomic insights into the genetic diversity and genetic basis of body height in endangered Chinese Ningqiang ponies.BMC genomics · 2025Article
- Efficient multi-phenotype genome-wide analysis identifies genetic associations for unsupervised deep-learning-derived high-dimensional brain imaging phenotypes.medRxiv : the preprint server for health sciences · 2024Article
- Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.Nature genetics · 2024Article
- Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.BMC medicine · 2024Article
- Cortical morphological changes and associated transcriptional signatures in post-traumatic stress disorder and psychological resilience.BMC medicine · 2024Article
- Multi-Omics Integration Analysis Pinpoint Proteins Influencing Brain Structure and Function: Toward Drug Targets and Neuroimaging Biomarkers for Neuropsychiatric Disorders.International journal of molecular sciences · 2024Article
- Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.medRxiv : the preprint server for health sciences · 2024Article
- Cross-ancestry genome-wide association studies of brain imaging phenotypes.Nature genetics · 2024Article
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Authors and funding
45 authors.
Nana Liu *Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
Longjiang Zhang *Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID 0000-0002-6664-7224
Tian Tian *Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-0224-2957
Jingliang ChengDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Bing ZhangDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Shijun QiuDepartment of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Zuojun GengDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Guangbin CuiFunctional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, China.
Quan ZhangDepartment of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, China.
Weihua LiaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Yongqiang YuDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Hui ZhangDepartment of Radiology, The First Hospital of Shanxi Medical University, Taiyuan, China.
Bo GaoDepartment of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Xiaojun XuDepartment of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.ORCID 0000-0002-0127-2812
Tong HanDepartment of Radiology, Tianjin Huanhu Hospital, Tianjin, China.
Zhenwei YaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Wen QinDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.ORCID 0000-0002-9121-8296
Feng LiuDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.ORCID 0000-0002-3570-4222
Meng LiangSchool of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China.
Qiang XuDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
Jilian FuDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
Jiayuan XuDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
Wenzhen ZhuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Peng ZhangDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Wei LiDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Dapeng ShiDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China.
Caihong WangDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Su LuiDepartment of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular lmaging key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Zhihan YanDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Feng ChenDepartment of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.ORCID 0000-0002-9129-7895
Jiance LiDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jing ZhangDepartment of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China.
Dawei WangDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Wen ShenDepartment of Radiology, Tianjin First Center Hospital, Tianjin, China.
Yanwei MiaoDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Junfang XianDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-2191-9393
Jia-Hong GaoCenter for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID 0000-0002-9311-0297
Xiaochu ZhangDivision of Life Science and Medicine, University of Science & Technology of China, Hefei, China.ORCID 0000-0002-7541-0130
Mulin Jun LiDepartment of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Kai XuDepartment of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Xi-Nian ZuoDevelopmental Population Neuroscience Research Center at IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.ORCID 0000-0001-9110-585X
Meiyun WangDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China. mywang@ha.edu.cn.ORCID 0000-0003-4454-5005
Zhaoxiang YeDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. yezhaoxiang@163.com.ORCID 0000-0003-3157-8393
Chunshui YuDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China. chunshuiyu@tmu.edu.cn.ORCID 0000-0001-5648-5199
CHIMGEN Consortium
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and its subfields differ in architecture and function. Genome-wide association studies on hippocampal and subfield volumes are mainly conducted in European populations; however, other ancestral populations are under-represented. Here we conduct cross-ancestry genome-wide association meta-analyses in 65,791 individuals for hippocampal volume and 38,977 for subfield volumes, including 7,009 individuals of East Asian ancestry. We identify 339 variant-trait associations at P < 1.13 × 10
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Genome-Wide Association StudyMagnetic Resonance ImagingCognitionHippocampusHumans
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