Evidence map›Paper›PMID 37337088›Full record

ArticleThe Journal of antibiotics2023

Antibacterial and antibiofilm activities of ZIF-67.

Ramses Gallegos-Monterrosa, Rodrigo Orozco Mendiola, Yoselin Nuñez, Constance Auvynet, Kesarla Mohan Kumar, Bin Tang, Leonardo I Ruiz-Ortega, Víctor H Bustamante

Open access · hybridAbstract read
In one paragraph

Article in The Journal of antibiotics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ramses Gallegos-MonterrosaDepartamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, C.P. 62210, Cuernavaca, Morelos, México.ORCID http://orcid.org/0000-0002-2366-0912
Rodrigo Orozco MendiolaInstituto de Ciencias Físicas, Universidad Nacional Autónoma de México, C.P. 62210, Cuernavaca, Morelos, México.
Yoselin NuñezDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, C.P. 62210, Cuernavaca, Morelos, México.
Constance AuvynetDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, C.P. 62210, Cuernavaca, Morelos, México.
Kesarla Mohan KumarInstituto de Ciencias Físicas, Universidad Nacional Autónoma de México, C.P. 62210, Cuernavaca, Morelos, México.
Bin TangDepartment of Biomedical Engineering, Southern University of Science and Technology, 1088 Xueyuan Avenue, Shenzhen, 518055, PR China.
Leonardo I Ruiz-OrtegaInstituto de Ciencias Físicas, Universidad Nacional Autónoma de México, C.P. 62210, Cuernavaca, Morelos, México. lr3113@columbia.edu.
Víctor H BustamanteDepartamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, C.P. 62210, Cuernavaca, Morelos, México. victor.bustamante@ibt.unam.mx.
Universidad Nacional Autónoma de México · MXColumbia University · USSouthern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, antibiotic-resistant bacteria represent a serious threat to public health worldwide. Biofilm formation potentiates both virulence and antibiotic resistance of bacteria. Therefore, the discovery of new antibacterial and antibiofilm compounds is an issue of paramount importance to combat and prevent hard-to-treat bacterial infections. Zeolitic-imidazolate-frameworks (ZIFs) are metallo-organic compounds known to have various interesting chemical and biological applications, including antibacterial properties. In this study, we synthesized ZIF-67 nanoparticles, formed by imidazolate anions and cobalt cations, and found that they inhibit the growth of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus. Sub-inhibitory concentrations of ZIF-67 were also able to significantly reduce the biomass of pre-established biofilms of these pathogenic bacteria. On the other hand, the ZIF-67 nanoparticles had null or low cytotoxicity in mammalian cells at those concentrations showing antibacterial or antibiofilm activities. Thus, our results reveal the potential of ZIF-67 nanoparticles to be used against pathogenic bacteria.

Indexed as

Anti-Bacterial AgentsImidazolesStaphylococcus aureusZeolitesAnimalsBacteriaBiofilmsMammalsMicrobial Sensitivity TestsAnti-Bacterial AgentsImidazolesZeoliteszeolitic imidazolate framework-67

Identifiers

PMID37337088
PMCPMC10522484
OpenAlexW4381252623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.