Evidence map›Paper›PMID 37336976›Full record

ArticleNature neuroscience2023

Gradients of neurotransmitter receptor expression in the macaque cortex.

Sean Froudist-Walsh, Ting Xu, Meiqi Niu, Lucija Rapan, Ling Zhao, Daniel S Margulies, Karl Zilles, Xiao-Jing Wang, Nicola Palomero-Gallagher

Open access · hybridAbstract read
In one paragraph

Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 96 citations in OpenAlex.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Sean Froudist-WalshComputational Neuroscience Unit, Faculty of Engineering, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-4070-067X
Ting XuChild Mind Institute, New York, NY, USA.ORCID http://orcid.org/0000-0002-0065-3832
Meiqi NiuInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Lucija RapanInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Ling ZhaoInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0003-0902-1425
Daniel S MarguliesIntegrative Neuroscience and Cognition Center, University of Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-8880-9204
Karl Zilles
Xiao-Jing WangCenter for Neural Science, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0003-3124-8474
Nicola Palomero-GallagherInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany. n.palomero-gallagher@fz-juelich.de.ORCID http://orcid.org/0000-0003-4463-8578
Forschungszentrum Jülich · DEChild Mind Institute · USNew York University · USUniversité Paris Cité · FRUniversity of Bristol · GB

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7M
Recurrent Neual Circuit Basis of Time Integration and Decision MakingR01MH062349 · NIMH · YALE UNIVERSITY · PI WANG, XIAO-JING · 2001 to 2022
$7.2M
Computer Aided Diagnostic System for Prostate Cancer Detection Using Quantitative Multiparametric MRIR01CA241159 · NCI · UNIVERSITY OF MINNESOTA · PI METZGER, GREGORY JOHN · 2021 to 2025
$3.0M
An Alignment Framework For Mapping Brain Dynamics and Substrates of Human Cognition Across SpeciesRF1MH128696 · NIMH · CHILD MIND INSTITUTE, INC. · PI XU, TING · 2021 to 2021
$1.2M
CRCNS: Gradients of receptors underlying distributed cognitive functions R01MH122024 · NIMH · NEW YORK UNIVERSITY · PI WANG, XIAO-JING · 2019 to 2021
$456k
Biotechnology and Biological Sciences Research Council BB/X013243/1NCI NIH HHS R01 CA241159NIBIB NIH HHS P41 EB027061NIMH NIH HHS R01 MH062349NIMH NIH HHS R01 MH122024NIMH NIH HHS RF1 MH128696NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization across cortical regions is needed. In this study, we used in vitro receptor autoradiography to measure the density of 14 neurotransmitter receptor types in 109 areas of macaque cortex. We integrated the receptor data with anatomical, genetic and functional connectivity data into a common cortical space. We uncovered a principal gradient of receptor expression per neuron. This aligns with the cortical hierarchy from sensory cortex to higher cognitive areas. A second gradient, driven by serotonin 5-HT

Indexed as

Brain MappingCerebral CortexReceptors, NeurotransmitterAgedAnimalsAutoradiographyCognitionDendritic SpinesFemaleGyrus CinguliHumansMacaca fascicularisMaleMyelin SheathRatsRats, Inbred LewReceptors, CholinergicReceptors, DopamineReceptor, Serotonin, 5-HT1AReceptors, NeurotransmitterSerotonin

Identifiers

PMID37336976
PMCPMC10322721
OpenAlexW4381189461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.