ArticleNature neuroscience2023
Control and coding of pupil size by hypothalamic orexin neurons.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Fluctuations in arousal reflect latent state transitions that facilitate behavioural optimization.Nature human behaviour · 2026Article
- Miniaturized Bidirectional Thermal Stimulation System Integrated With an Electrode Array for Recording Neural Activities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The anterior cingulate cortex modulates pupil-linked arousal.Science advances · 2026Article
- Sound-evoked pupil dilation quantifies misophonic symptoms.PloS one · 2026Article
- Neuropeptides and the Autonomic Nervous System in Prader-Willi Syndrome.International journal of molecular sciences · 2025Review
- Measuring Mental Effort in Real Time Using Pupillometry.Journal of eye movement research · 2025Article
- Catecholamines reduce choice history biases in perceptual decision making.PLoS biology · 2025Article
- Orexin population activity precisely reflects net body movement across behavioral and metabolic states.eLife · 2025Article
- The Interplay Between Tonic and Phasic Pupil Activity and Cognitive Flexibility and Stability.Psychophysiology · 2025Article
- Basal Forebrain to Ventral Tegmental Area Glutamatergic Pathway Promotes Emergence from Isoflurane Anesthesia in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Modulating cortical excitability and cortical arousal by pupil self-regulation.Nature communications · 2025Article
- Arousal state fluctuations are a source of internal noise underlying age-related declines in speech intelligibility.bioRxiv : the preprint server for biology · 2025Article
- Pupil size reveals arousal level fluctuations in human sleep.Nature communications · 2025Article
- Probing locus coeruleus functional network in healthy aging and its association with Alzheimer's disease biomarkers using pupillometry.Alzheimer's research & therapy · 2025Article
- Higher-order thalamic input to cortex selectively conveys state information.Cell reports · 2025Article
- Pupillometric and perceptual approaches provide independent estimates of melanopsin activity in humans.Sleep · 2025Article
- Noradrenergic therapies in neurodegenerative disease: from symptomatic to disease modifying therapy?Brain communications · 2025Review
- Pupil Dynamics Predict Exercise Brain Stimulation: An Overview of Exercise Pupillometry.Advances in neurobiology · 2025Review
- Strategic stabilization of arousal boosts sustained attention.Current biology : CB · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain orexin (hypocretin) neurons are implicated in sleep-wake switching and reward-seeking but their roles in rapid arousal dynamics and reward perception are unclear. Here, cell-specific stimulation, deletion and in vivo recordings revealed strong correlative and causal links between pupil dilation-a quantitative arousal marker-and orexin cell activity. Coding of arousal and reward was distributed across orexin cells, indicating that they specialize in rapid, multiplexed communication of momentary arousal and reward states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.