Evidence map›Paper›PMID 37336874›Full record

ArticleNature communications2023

Neural correlates of hierarchical predictive processes in autistic adults.

Laurie-Anne Sapey-Triomphe, Lauren Pattyn, Veith Weilnhammer, Philipp Sterzer, Johan Wagemans

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Systematic Review and Meta-Analysis of Mismatch Negativity in Autism: Insights Into Predictive Mechanisms.Autism research : official journal of the International Society for Autism Research · 2025
    Pooled it
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  12. Bayesian Workflow for Generative Modeling in Computational Psychiatry.Computational psychiatry (Cambridge, Mass.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Laurie-Anne Sapey-TriompheDepartment of Brain and Cognition, Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium. laurie-anne.sapey-triomphe@inserm.fr.ORCID 0000-0002-6564-5892
Lauren PattynDepartment of Brain and Cognition, Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium.
Veith WeilnhammerDepartment of Psychiatry, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
Philipp SterzerDepartment of Psychiatry, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.ORCID 0000-0003-4687-2317
Johan WagemansDepartment of Brain and Cognition, Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium.ORCID 0000-0002-7970-1541
Berlin Institute of Health at Charité - Universitätsmedizin Berlin · DEVIB-KU Leuven Center for Brain & Disease Research · BEAllen Institute for Brain Science · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bayesian theories of autism spectrum disorders (ASD) suggest that atypical predictive mechanisms could underlie the autistic symptomatology, but little is known about their neural correlates. Twenty-six neurotypical (NT) and 26 autistic adults participated in an fMRI study where they performed an associative learning task in a volatile environment. By inverting a model of perceptual inference, we characterized the neural correlates of hierarchically structured predictions and prediction errors in ASD. Behaviorally, the predictive abilities of autistic adults were intact. Neurally, predictions were encoded hierarchically in both NT and ASD participants and biased their percepts. High-level predictions were following activity levels in a set of regions more closely in ASD than NT. Prediction errors yielded activation in shared regions in NT and ASD, but group differences were found in the anterior cingulate cortex and putamen. This study sheds light on the neural specificities of ASD that might underlie atypical predictive processing.

Indexed as

Autism Spectrum DisorderAutistic DisorderAdultBayes TheoremHumansMagnetic Resonance Imaging

Identifiers

PMID37336874
PMCPMC10279690
OpenAlexW4381249236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.