ArticleInsights into imaging2023
An overview of meta-analyses on radiomics: more evidence is needed to support clinical translation.
Article in Insights into imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Pooled it
- Teledentistry for Improving Access To, and Quality of Oral Health Care: Overview of Systematic Reviews and Meta-Analyses.Journal of medical Internet research · 2025Pooled it
- Assessment of Robustness of MRI Radiomic Features in Four Abdominal Organs: Impact of Deep Learning Reconstruction and Segmentation.Journal of magnetic resonance imaging : JMRI · 2026Article
- Why Radiomics Rarely Reaches the Clinic: Reproducibility, Validation, and Evidence Gap-A Critical Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Assessment of Robustness of MRI Radiomic Features in the Abdomen: Impact of Deep Learning Reconstruction and Accelerated Acquisition.Journal of imaging informatics in medicine · 2026Article
- Multicenter peritumoral radiomics in oncology: advances, challenges, and future directions.Radiation oncology (London, England) · 2026Review
- Explanation and Elaboration with Examples for METRICS (METRICS-E3): an initiative from the EuSoMII Radiomics Auditing Group.Insights into imaging · 2025Article
- Two independent studies, one goal, one conclusion: radiomics research quality under the microscope.European radiology · 2025Article
- Reproducibility of methodological radiomics score (METRICS): an intra- and inter-rater reliability study endorsed by EuSoMII.European radiology · 2025Article
- Robustness of radiomics within photon-counting detector CT: impact of acquisition and reconstruction factors.European radiology · 2025Article
- Deep learning image enhancement algorithms in PET/CT imaging: a phantom and sarcoma patient radiomic evaluation.European journal of nuclear medicine and molecular imaging · 2025Article
- ChatGPT as an effective tool for quality evaluation of radiomics research.European radiology · 2025Article
- Quality of radiomics research: comprehensive analysis of 1574 unique publications from 89 reviews.European radiology · 2025Article
- Overlooked and underpowered: a meta-research addressing sample size in radiomics prediction models for binary outcomes.European radiology · 2025Article
- Robustness of radiomics among photon-counting detector CT and dual-energy CT systems: a texture phantom study.European radiology · 2025Article
- Article
- Exploring radiomics research quality scoring tools: a comparative analysis of METRICS and RQSDiagnostic and interventional radiology (Ankara, Turkey) · 2024Article
- Decoding Radiomics: A Step-by-Step Guide to Machine Learning Workflow in Hand-Crafted and Deep Learning Radiomics Studies.Diagnostics (Basel, Switzerland) · 2024Review
- Self-reported checklists and quality scoring tools in radiomics: a meta-research.European radiology · 2024Article
- Explanation and Elaboration with Examples for CLEAR (CLEAR-E3): an EuSoMII Radiomics Auditing Group Initiative.European radiology experimental · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo conduct an overview of meta-analyses of radiomics studies assessing their study quality and evidence level.
methodsA systematical search was updated via peer-reviewed electronic databases, preprint servers, and systematic review protocol registers until 15 November 2022. Systematic reviews with meta-analysis of primary radiomics studies were included. Their reporting transparency, methodological quality, and risk of bias were assessed by PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) 2020 checklist, AMSTAR-2 (A MeaSurement Tool to Assess systematic Reviews, version 2) tool, and ROBIS (Risk Of Bias In Systematic reviews) tool, respectively. The evidence level supporting the radiomics for clinical use was rated.
resultsWe identified 44 systematic reviews with meta-analyses on radiomics research. The mean ± standard deviation of PRISMA adherence rate was 65 ± 9%. The AMSTAR-2 tool rated 5 and 39 systematic reviews as low and critically low confidence, respectively. The ROBIS assessment resulted low, unclear and high risk in 5, 11, and 28 systematic reviews, respectively. We reperformed 53 meta-analyses in 38 included systematic reviews. There were 3, 7, and 43 meta-analyses rated as convincing, highly suggestive, and weak levels of evidence, respectively. The convincing level of evidence was rated in (1) T2-FLAIR radiomics for IDH-mutant vs IDH-wide type differentiation in low-grade glioma, (2) CT radiomics for COVID-19 vs other viral pneumonia differentiation, and (3) MRI radiomics for high-grade glioma vs brain metastasis differentiation.
conclusionsThe systematic reviews on radiomics were with suboptimal quality. A limited number of radiomics approaches were supported by convincing level of evidence. CLINICAL RELEVANCE STATEMENT: The evidence supporting the clinical application of radiomics are insufficient, calling for researches translating radiomics from an academic tool to a practicable adjunct towards clinical deployment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.