Evidence map›Paper›PMID 37336762›Full record

ArticleAnalytical chemistry2023

High Sensitivity Extended Nano-Coulter Counter for Detection of Viral Particles and Extracellular Vesicles.

Swarnagowri Vaidyanathan, Harshani Wijerathne, Sachindra S T Gamage, Farhad Shiri, Zheng Zhao, Junseo Choi, Sunggook Park, Małgorzata A Witek, Collin McKinney, Matthew Verber and 7 more

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  9. Integrated In-Plane Nanofluidic Devices for Resistive-Pulse Sensing.Annual review of analytical chemistry (Palo Alto, Calif.) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Swarnagowri VaidyanathanBioengineering Program, The University of Kansas, Lawrence, Kansas 66045, United States.
Harshani WijerathneDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
Sachindra S T GamageDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0002-7507-3226
Farhad ShiriDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
Zheng ZhaoBioengineering Program, The University of Kansas, Lawrence, Kansas 66045, United States.
Junseo ChoiCenter of BioModular Multiscale Systems for Precision Medicine, The University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0002-3461-3820
Sunggook ParkCenter of BioModular Multiscale Systems for Precision Medicine, The University of Kansas, Lawrence, Kansas 66045, United States.
Małgorzata A WitekDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
Collin McKinneyDepartment of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27514, United States.
Matthew VerberDepartment of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27514, United States.
Adam R HallCenter of BioModular Multiscale Systems for Precision Medicine, The University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0003-2053-6075
Katie ChildersBioengineering Program, The University of Kansas, Lawrence, Kansas 66045, United States.
Taryn McNickleDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
Shalee MogDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
Elaine YehDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
Andrew K GodwinCenter of BioModular Multiscale Systems for Precision Medicine, The University of Kansas, Lawrence, Kansas 66045, United States.
Steven A SoperBioengineering Program, The University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0002-8292-7058
University of Kansas · USLouisiana State University · USUniversity of North Carolina at Chapel Hill · US

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Kalyani Pyaram, Steven Allan Soper · 2019 to 2026
$21.5M
Single-Molecule Processing: Detection and Identification of Single DNAs, RNAs, and Proteins using Immobilized Nanoscale Enzymatic Reactors (INERs) and Nanoscale ElectrophoresisP41EB020594 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Adam Roger Hall · 2015 to 2026
$15.2M
Synthetic Chemical Biology CoreP30GM145499 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Susan M Lunte · 2022 to 2026
$6.9M
mRNA Expression Profiling from Extracellular Vesicles (EVs): Generating a Rapid Diagnostic for StrokeR01EB031579 · NIBIB · UNIVERSITY OF KANSAS LAWRENCE · PI BAIRD, ALISON E, SOPER, STEVEN ALLAN · 2022 to 2025
$2.3M
NCI NIH HHS P30 CA168524NIBIB NIH HHS P41 EB020594NIBIB NIH HHS R01 EB031579NIGMS NIH HHS P20 GM103638NIGMS NIH HHS P20 GM130423NIGMS NIH HHS P30 GM145499
6 · The paper itself

Abstract

We present a chip-based extended nano-Coulter counter (XnCC) that can detect nanoparticles affinity-selected from biological samples with low concentration limit-of-detection that surpasses existing resistive pulse sensors by 2-3 orders of magnitude. The XnCC was engineered to contain 5 in-plane pores each with an effective diameter of 350 nm placed in parallel and can provide high detection efficiency for single particles translocating both hydrodynamically and electrokinetically through these pores. The XnCC was fabricated in cyclic olefin polymer (COP) via nanoinjection molding to allow for high-scale production. The concentration limit-of-detection of the XnCC was 5.5 × 10

Indexed as

COVID-19Extracellular VesiclesNanoparticlesHumansSARS-CoV-2Virion

Identifiers

PMID37336762
PMCPMC11015478
OpenAlexW4381187299

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.