Evidence map›Paper›PMID 37336284›Full record

ArticleCancer letters2023

A complex of Wnt/planar cell polarity signaling components Vangl1 and Fzd7 drives glioblastoma multiforme malignant properties.

Courtney A Dreyer, Kacey VanderVorst, Dean Natwick, George Bell, Prachi Sood, Maria Hernandez, James M Angelastro, Sean R Collins, Kermit L Carraway

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Courtney A DreyerDepartment of Biochemistry and Molecular Medicine and University of California Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA, USA.
Kacey VanderVorstDepartment of Biochemistry and Molecular Medicine and University of California Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA, USA.
Dean NatwickDepartment of Microbiology and Molecular Genetics, University of California Davis, Davis, CA, USA.
George BellDepartment of Microbiology and Molecular Genetics, University of California Davis, Davis, CA, USA.
Prachi SoodDepartment of Biochemistry and Molecular Medicine and University of California Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA, USA.
Maria HernandezDepartment of Biochemistry and Molecular Medicine and University of California Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA, USA.
James M AngelastroDepartment of Molecular Biosciences, University of California Davis School of Veterinary Medicine, Davis, CA, USA.
Sean R CollinsDepartment of Microbiology and Molecular Genetics, University of California Davis, Davis, CA, USA.
Kermit L CarrawayDepartment of Biochemistry and Molecular Medicine and University of California Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA, USA. Electronic address: klcarraway@ucdavis.edu.
University of California, Davis · US

Funding

Rewiring Control of Leukocyte Motility for Therapeutic ApplicationDP2HD094656 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COLLINS, SEAN RYAN · 2017 to 2017
$2.4M
Planar cell polarity pathway contribution to breast cancer metastasisR01CA230742 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARRAWAY, KERMIT L · 2019 to 2023
$2.0M
Vangl Dependent PCP Signaling Mediates EMT Induced Cell InvasivenessF31CA210467 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VANDERVORST, KACEY · 2016 to 2018
$116k
Wnt/Planar Cell Polarity Contribution to Glioblastoma Multiforme Invasion and Therapeutic ResistanceF31CA246900 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DREYER, COURTNEY ANNE · 2020 to 2022
$115k
Optogenetic approaches to dissect Rho GTPase signal transduction during neutrophil responses to inflammationF31HL152621 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NATWICK, DEAN EDWARD · 2020 to 2020
$38k
NCI NIH HHS F31 CA210467NCI NIH HHS F31 CA246900NCI NIH HHS R01 CA230742NHLBI NIH HHS F31 HL152621NICHD NIH HHS DP2 HD094656
6 · The paper itself

Abstract

Targeting common oncogenic drivers of glioblastoma multiforme (GBM) in patients has remained largely ineffective, raising the possibility that alternative pathways may contribute to tumor aggressiveness. Here we demonstrate that Vangl1 and Fzd7, components of the non-canonical Wnt planar cell polarity (Wnt/PCP) signaling pathway, promote GBM malignancy by driving cellular proliferation, migration, and invasiveness, and engage Rho GTPases to promote cytoskeletal rearrangements and actin dynamics in migrating GBM cells. Mechanistically, we uncover the existence of a novel Vangl1/Fzd7 complex at the leading edge of migrating GBM cells and propose that this complex is critical for the recruitment of downstream effectors to promote tumor progression. Moreover, we observe that depletion of FZD7 results in a striking suppression of tumor growth and latency and extends overall survival in an intracranial mouse xenograft model. Our observations support a novel mechanism by which Wnt/PCP components Vangl1 and Fzd7 form a complex at the leading edge of migratory GBM cells to engage downstream effectors that promote actin cytoskeletal rearrangements dynamics. Our findings suggest that interference with Wnt/PCP pathway function may offer a novel therapeutic strategy for patients diagnosed with GBM.

Indexed as

GlioblastomaActinsAnimalsCell Line, TumorCell PolarityCell ProliferationHumansMiceWnt Signaling PathwayActinsGlioblastomaMotilityNoncanonical Wnt signalingPlanar cell polarityProliferation

Identifiers

PMID37336284
PMCPMC10582999
OpenAlexW4381033557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.