ArticlePlacenta2023
Patterns of placental pathology associated with preeclampsia.
Article in Placenta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 20 citations in OpenAlex.
- Associations of Serum Inflammatory Biomarkers During Pregnancy With Placental Pathology and Placental Gene Expression at Delivery.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Trial
- Pregnancy-related disorders: molecular mechanisms and management.Molecular biomedicine · 2026Review
- The predictive value of early-pregnancy mean platelet volume for preeclampsia: A meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2026Review
- Can placental histology reveal preexisting hypertension in patients who develop preeclampsia?Journal of hypertension · 2026Article
- Placental Pathology in preeclampsia and gestational hypertension; A comparative study.Pakistan journal of medical sciences · 2026Article
- Retinal and Choroidal Metrics Are Dynamic Markers of the Maternal Vascular Response to Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Risk of Placental Pathology Across Ultrasound-Defined Phenotypes of Impaired Fetal Growth in Dichorionic Twins: A Retrospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Hypoalbuminemia as a severity predictor of preeclampsia in a multicenter study from Indonesia.Scientific reports · 2026Article
- Integrated molecular and histological profiling of preeclampsia suggests angiogenic dysregulation associated with maternal and fetal outcomes.Scientific reports · 2026Article
- Determinants of Placental Versus Maternal Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Characterizing placental dysfunction with DNA methylation profiling and placental histopathology.Placenta · 2026Article
- A placental DNA methylation score associated with early-onset preeclampsia and maternal vascular malperfusion pathology.Frontiers in epigenetics and epigenomics · 2026Article
- Cumulative burden of maternal vascular malperfusion and its association with early cerebral oxygenation in neonates.Frontiers in cell and developmental biology · 2026Article
- Evaluation of oxidative stress markers and the angiogenic factors in preeclampsia and associated features.BMC pregnancy and childbirth · 2025Article
- HIF-1A Expression in Placenta of Pregnancies Complicated with Preeclampsia and Fetal Growth Restriction.Diagnostics (Basel, Switzerland) · 2025Article
- Placental Pathology and Blood Pressure at Age 7: A Longitudinal Discordant Twin Analysis.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Identifying causes and associated factors of stillbirths using autopsy of the fetus and placenta.Archives of gynecology and obstetrics · 2025Observational
- Molecular signatures of preeclampsia subtypes determined through integrated weighted gene co-expression network analysis and differential gene expression analysis of placental transcriptomics.Frontiers in cell and developmental biology · 2025Article
- Nutraceuticals as Modulators of Molecular Placental Pathways: Their Potential to Prevent and Support the Treatment of Preeclampsia.International journal of molecular sciences · 2024Review
- Placental differences between severe fetal growth restriction and hypertensive disorders of pregnancy requiring early preterm delivery: morphometric analysis of the villous tree supported by artificial intelligence.American journal of obstetrics and gynecology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
introductionMaternal vascular malperfusion (MVM) is commonly observed in early onset preeclampsia, but less prevalent in late onset preeclampsia. The purpose of our analysis was to investigate patterns of placental pathology in preeclampsia.
methodsElectronic health records for all singleton livebirths from 2009 to 2018 at a single institution with a diagnosis of preeclampsia were obtained. Text searching was used to obtain placental data from pathology reports, including lesions of MVM, fetal vascular malperfusion (FVM), chronic inflammation (CI), and acute inflammation (AI). Placental pathology was compared based on timing of delivery and latent class analysis (LCA) was used to investigate subtypes of preeclampsia based on 22 placental variables.
results728 patients were included in the analysis. Prevalence of MVM decreased with advancing gestation (95.4% at <34 weeks, 69.8% at 34-36 weeks, and 50%, ≥37 weeks; p < 0.01). LCA identified five classes based on placental pathology: (1) high grade MVM, (2) CI and FVM, (3) low grade MVM, (4) AI, (5) other. Preterm birth varied across the classes (p < 0.01), with the highest prevalence observed among the classes characterized by MVM (high grade: 87.6%; low grade: 63.0%) and the lowest prevalence among the class characterized by AI (23.5%). DISCUSSION: Placental pathology in preeclampsia differs based on gestational age at delivery with MVM seen in nearly all early onset preeclampsia cases. Latent classes largely grouped by previously defined patterns of placental injury (MVM, CI, FVM, AI), and again revealed the highest likelihood of preterm birth in classes characterized by MVM. Results suggest there may be multiple mechanisms leading to the clinical manifestations of preeclampsia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.