Evidence map›Paper›PMID 37335991›Full record

ArticleAnnals of internal medicine2023

Clinical Characteristics and Outcomes Among Travelers With Severe Dengue : A GeoSentinel Analysis.

Ralph Huits, Kristina M Angelo, Bhawana Amatya, Sapha Barkati, Elizabeth D Barnett, Emmanuel Bottieau, Hannah Emetulu, Loïc Epelboin, Gilles Eperon, Line Medebb and 16 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 20 institutions in 14 countries.

Ralph HuitsDepartment of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy (R.H.).ORCID 0000-0001-8803-9468
Kristina M AngeloDivision of Global Migration and Quarantine, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia (K.M.A.).ORCID 0000-0001-7665-7875
Bhawana AmatyaCIWEC Hospital and Travel Medicine Center, Kathmandu, Nepal (B.A.).ORCID 0000-0001-9888-4702
Sapha BarkatiJ.D. MacLean Centre for Tropical Diseases, McGill University Health Centre, Montreal, Quebec, Canada (S.B.).ORCID 0000-0002-9388-855X
Elizabeth D BarnettSection of Pediatric Infectious Diseases, Boston Medical Center, Boston, Massachusetts (E.D.B., M.L.).
Emmanuel BottieauDepartment of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium (E.B.).ORCID 0000-0002-5868-7760
Hannah EmetuluInternational Society of Travel Medicine, Atlanta, Georgia (H.E., A.R.).
Loïc EpelboinInfectious and Tropical Diseases Unit and CIC Inserm 1424, Centre Hospitalier de Cayenne, Cayenne, French Guiana (L.E.).ORCID 0000-0002-3481-5991
Gilles EperonDivision of Tropical and Humanitarian Medicine, Geneva University Hospitals, Geneva, Switzerland (G.E.).ORCID 0000-0002-3371-4320
Line MedebbAix Marseille University, AP-HM, IHU-Méditerranée Infection, Marseille, France (L.M.).
Federico GobbiDepartment of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Verona, and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy (F.G.).
Martin P GrobuschCenter of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Amsterdam University Medical Center, Amsterdam, the Netherlands (M.P.G.).ORCID 0000-0002-0046-1099
Oula ItaniInstitut Pasteur, Centre Médical, Centre d'Infectiologie Necker-Pasteur, Paris, France (O.I.).
Sabine JordanDivision of Tropical Medicine, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, and Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (S.J.).
Paul KellyBronxCare Hospital Center, Bronx, New York (P.K.).
Karin LederSchool of Public Health and Preventive Medicine, Monash University, and Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Victoria, Australia (K.L.).ORCID 0000-0003-1368-1039
Marta Díaz-MenéndezTropical Medicine Department, Hospital Universitario La Paz-Carlos III, IdIPAz, and CIBERINFECT, Madrid, Spain (M.D.).ORCID 0000-0002-9427-5237
Nobumasa OkumuraCenter Hospital of the National Center for Global Health and Medicine, Shinjuku City, Tokyo, Japan (N.O.).ORCID 0000-0002-0434-4842
Aisha RizwanInternational Society of Travel Medicine, Atlanta, Georgia (H.E., A.R.).
Camilla RotheDepartment of Infectious Diseases and Tropical Medicine, Ludwig-Maximilians-Universität München, Munich, Germany (C.R.).
Mauro SaioDoctor's Plaza, Nairobi Hospital, Nairobi, Kenya (M.S.).ORCID 0009-0004-9321-3642
Jesse WaggonerDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia (J.W.).ORCID 0000-0002-0244-5957
Yukihiro YoshimuraYokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan (Y.Y.).ORCID 0000-0002-5046-7819
Michael LibmanSection of Pediatric Infectious Diseases, Boston Medical Center, Boston, Massachusetts (E.D.B., M.L.).ORCID 0000-0003-3416-6482
Davidson H HamerDepartment of Global Health, Boston University School of Public Health, Section of Infectious Diseases, Boston University School of Medicine, Center for Emerging Infectious Disease Policy and Research, Boston University, and National Emerging Infectious Disease Laboratory, Boston, Massachusetts (D.H.H.).ORCID 0000-0002-4700-1495
Eli SchwartzThe Center of Geographical Medicine and Tropical Diseases, Sheba Medical Center, Tel HaShomer, and Ramat Gan & Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel (E.S.).
Boston Medical Center · USInternational Society of Travel Medicine · USOspedale Sacro Cuore Don Calabria · ITAix-Marseille Université · FRBoston University · USCenters for Disease Control and Prevention · USCentre Hospitalier Andrée Rosemon · GFCivil Service Hospital · NPEmory University · USHospital Universitario La Paz · ESInstitut Pasteur · FRInstituut voor Tropische Geneeskunde · BELudwig-Maximilians-Universität München · DEMcGill University Health Centre · CANairobi Hospital · KENational Center for Global Health and Medicine · JPSheba Medical Center · ILThe Royal Melbourne Hospital · AUUniversität Hamburg · DEUniversity Hospital of Geneva · CH

Funding

Intramural CDC HHS CC999999NCEZID CDC HHS U01 CK000632NCEZID CDC HHS U50 CK000189
6 · The paper itself

Abstract

backgroundDengue virus is a flavivirus transmitted by

objectiveTo describe the epidemiology, clinical characteristics, and outcomes among international travelers with severe dengue or dengue with warning signs as defined by the 2009 World Health Organization classification (that is, complicated dengue).

designRetrospective chart review and analysis of travelers with complicated dengue reported to GeoSentinel from January 2007 through July 2022.

setting20 of 71 international GeoSentinel sites. PATIENTS: Returning travelers with complicated dengue. MEASUREMENTS: Routinely collected surveillance data plus chart review with abstraction of clinical information using predefined grading criteria to characterize the manifestations of complicated dengue.

resultsOf 5958 patients with dengue, 95 (2%) had complicated dengue. Eighty-six (91%) patients had a supplemental questionnaire completed. Eighty-five of 86 (99%) patients had warning signs, and 27 (31%) were classified as severe. Median age was 34 years (range, 8 to 91 years); 48 (56%) were female. Patients acquired dengue most frequently in the Caribbean ( LIMITATIONS: Data for some variables could not be retrieved by chart review for some patients. The generalizability of our observations may be limited.

conclusionComplicated dengue is relatively rare in travelers. Clinicians should monitor patients with dengue closely for warning signs that may indicate progression to severe disease. Risk factors for developing complications of dengue in travelers need further prospective study. PRIMARY FUNDING SOURCE: Centers for Disease Control and Prevention, International Society of Travel Medicine, Public Health Agency of Canada, and GeoSentinel Foundation.

Indexed as

Severe DengueAdultFemaleHumansImmunoglobulin GImmunoglobulin MMaleProspective StudiesRetrospective StudiesTravelImmunoglobulin GImmunoglobulin M

Identifiers

PMID37335991
PMCPMC10760980
OpenAlexW4381185917

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.