Evidence map›Paper›PMID 37335834›Full record

ArticleMagnetic resonance in medicine2023

Comparison of model-free Lorentzian and spinlock model-based fittings in quantitative CEST imaging of acute stroke.

Limin Wu, Dongshuang Lu, Phillip Zhe Sun

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Limited Contribution of TMolecular imaging and biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Quasi-steady-state (QUASS) reconstruction enhances TMagnetic resonance in medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Limin WuMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Dongshuang LuMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phillip Zhe SunMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-4872-1192
Harvard University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Establishment of fast pH MRI for imaging metabolic injury during acute strokeR01NS083654 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Phillip Zhe Sun · 2013 to 2026
$4.0M
NCATS NIH HHS UL1 TR002378NIH HHS P51 OD011132NINDS NIH HHS R01 NS083654NINDS NIH HHS R01NS083654
6 · The paper itself

Abstract

purposeCEST MRI detects complex tissue changes following acute stroke. Our study aimed to test if spinlock model-based fitting of the quasi-steady-state (QUASS)-reconstructed equilibrium CEST MRI improves the determination of multi-pool signal changes over the commonly-used model-free Lorentzian fitting in acute stroke. THEORY AND

methodsMultiple three-pool CEST Z-spectra were simulated using Bloch-McConnell equations for a range of T

resultsThe spinlock model-based fitting of QUASS CEST MRI provided a nearly T

conclusionOur study demonstrated that spinlock model-based fitting of QUASS CEST MRI improved the determination of the underlying tissue changes following acute stroke, promising further clinical translation of quantitative CEST imaging.

Indexed as

Multiparametric Magnetic Resonance ImagingStrokeAmidesAnimalsMagnetic Resonance ImagingRatsAmidesamide proton transfer (APT)chemical exchange saturation transfer (CEST)pHquantitative CEST (qCEST)quasi-steady state (QUASS)stroke

Identifiers

PMID37335834
PMCPMC10538953
OpenAlexW4381163691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.