ReviewMethods in molecular biology (Clifton, N.J.)2023
K-Mer-Based Genome Size Estimation in Theory and Practice.
Review in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Chromosome-scale Genome Assembly and Annotation of Anise Hyssop (Agastache foeniculum).Scientific data · 2026Article
- Pan-genome based on chromosome sequences of wild and cultivated Agaricus bisporus.Scientific data · 2026Article
- Nuclear genome profiling of two species ofNAR genomics and bioinformatics · 2026Article
- Eupentacta fraudatrix: the first chromosome-level holothurian genome with extraordinarily high heterozygosity.Scientific data · 2026Article
- The genome of the medicinal plant Uncaria rhynchophylla provides new insights into monoterpenoid indole alkaloid metabolism and its molecular regulatory mechanism.Molecular horticulture · 2026Article
- Chromosome-level genome assembly and annotation of the endangered plant Primula kwangtungensis (Primulaceae).Scientific data · 2026Article
- Identification of genome size and heterozygosity in 510 Jujube (Frontiers in plant science · 2026Article
- Chromosome-level genome assembly of Schizodactylus jimo He, 2021 from China (Ensifera: Schizodactylidae).Scientific data · 2025Article
- A haplotype-resolved genome assembly of Anoectochilus roxburghii.Scientific data · 2025Article
- Chromosome-level genome assembly of the sea cucumber, Colochirus anceps.Scientific data · 2025Article
- A closed-loop method for precise genome size estimation using HiFi reads.BMC genomics · 2025Article
- CG-Based Stratification of 8-mers Highlights Functional Roles and Phylogenetic Divergence Markers.International journal of molecular sciences · 2025Article
- Genome analyses provide insights intoPlant diversity · 2025Article
- Chromosome level genome assembly of 'Wanfeng' almond (Prunus dulcis).Scientific data · 2025Article
- Chromosome-level genome assembly of the cave leech Sinospelaeobdella cavatuses (Hirudinea: Haemadipsidae).Scientific data · 2024Article
- A high-quality chromosome-level genome assembly of the endangered tree Kmeria septentrionalis.Scientific data · 2024Article
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1 author.
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Abstract
Recent advances in sequencing technologies have made genome sequencing of non-model organisms with very large and complex genomes possible. The data can be used to estimate diverse genome characteristics, including genome size, repeat content, and levels of heterozygosity. K-mer analysis is a powerful biocomputational approach with a wide range of applications, including estimation of genome sizes. However, interpretation of the results is not always straightforward. Here, I review k-mer-based genome size estimation, focusing specifically on k-mer theory and peak calling in k-mer frequency histograms. I highlight common pitfalls in data analysis and result interpretation, and provide a comprehensive overview on current methods and programs developed to conduct these analyses.
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