Evidence map›Paper›PMID 37335050›Full record

ArticleTissue engineering. Part C, Methods2023

Regenerative Engineering of a Biphasic Patient-Fitted Temporomandibular Joint Condylar Prosthesis.

David S Nedrelow, Ali Rassi, Boushra Ajeeb, Cameron P Jones, Pedro Huebner, Fabio G Ritto, Wendy R Williams, Kar-Ming Fung, Bradford W Gildon, Jakob M Townsend and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part C, Methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

David S NedrelowStephenson School of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma, USA.
Ali RassiSchool of Industrial and Systems Engineering, University of Oklahoma, Norman, Oklahoma, USA.
Boushra AjeebStephenson School of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma, USA.
Cameron P JonesCollege of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Pedro HuebnerSchool of Industrial and Systems Engineering, University of Oklahoma, Norman, Oklahoma, USA.
Fabio G RittoDepartment of Oral and Maxillofacial Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Wendy R WilliamsDivision of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Kar-Ming FungDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Bradford W GildonDepartment of Medical Imaging and Radiation Sciences, University of Oklahoma College of Allied Health, Oklahoma City, Oklahoma, USA.
Jakob M TownsendStephenson School of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma, USA.
Michael S DetamoreStephenson School of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma, USA.
University of Oklahoma · USUniversity of Oklahoma Health Sciences Center · USUniversity of Oklahoma Medical Center · US

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Wade Williams · 2018 to 2026
$27.1M
TUMOR RESISTANCE MECHANISMS TO ANTI-VEGF THERAPY IN PROSTATE CANCER (Sukyung Woo)P20GM103639 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DHANASEKARAN, DANNY N. · 2012 to 2022
$21.3M
NCI NIH HHS P30 CA225520NIGMS NIH HHS P20 GM103639
6 · The paper itself

Abstract

Regenerative medicine approaches to restore the mandibular condyle of the temporomandibular joint (TMJ) may fill an unmet patient need. In this study, a method to implant an acellular regenerative TMJ prosthesis was developed for orthotopic implantation in a pilot goat study. The scaffold incorporated a porous, polycaprolactone-hydroxyapatite (PCL-HAp, 20wt% HAp) 3D printed condyle with a cartilage-matrix-containing hydrogel. A series of material characterizations was used to determine the structure, fluid transport, and mechanical properties of 3D printed PCL-HAp. To promote marrow uptake for cell seeding, a scaffold pore size of 152 ± 68 μm resulted in a whole blood transport initial velocity of 3.7 ± 1.2 mm·s

Indexed as

Temporomandibular JointTissue ScaffoldsAnimalsBone and BonesGoatsTemporomandibular Joint DiscTissue Engineering3D printedchondrogenicgoathydroxyapatiteosteogenicpolycaprolactone

Identifiers

PMID37335050
PMCPMC10402699
OpenAlexW4381192810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.