Evidence map›Paper›PMID 37334915›Full record

ArticleThe Annals of otology, rhinology, and laryngology2024

Safety and Feasibility of Steroid-Eluting Stent as a Bolster in Endoscopic Anterior Skull Base Reconstruction.

John B Finlay, Khalil Issa, Feras Ackall, Ali Zomorodi, Patrick Codd, David W Jang, Bradley J Goldstein, Ralph Abi Hachem

Open access · greenAbstract read
In one paragraph

Article in The Annals of otology, rhinology, and laryngology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

John B FinlayDepartment of Head and Neck Surgery and Communication Sciences, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-3038-1276
Khalil IssaDepartment of Head and Neck Surgery and Communication Sciences, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-1899-5109
Feras AckallDepartment of Head and Neck Surgery and Communication Sciences, Duke University School of Medicine, Durham, NC, USA.
Ali ZomorodiDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.
Patrick CoddDepartment of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.
David W JangDepartment of Head and Neck Surgery and Communication Sciences, Duke University School of Medicine, Durham, NC, USA.
Bradley J GoldsteinDepartment of Head and Neck Surgery and Communication Sciences, Duke University School of Medicine, Durham, NC, USA.
Ralph Abi HachemDepartment of Head and Neck Surgery and Communication Sciences, Duke University School of Medicine, Durham, NC, USA.
Duke University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
NIGMS NIH HHS T32 GM007171NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

backgroundWith a rising incidence of cerebrospinal fluid (CSF) leaks, endoscopic endonasal CSF leak repair is increasingly performed. Current approaches utilize a variety of materials including free mucosal grafts and vascularized flaps, but post-op leaks continue to be reported. Steroid-eluting bioabsorbable stents (SES) are used during functional endoscopic sinus surgery for chronic rhinosinusitis to reduce inflammation and scarring while maintaining patency of sinus ostia.

objectiveThe aim of this study is to assess the feasibility of SES as a graft/flap bolster for endoscopic endonasal CSF leak repair.

methodsThis is a retrospective review of patients undergoing endoscopic endonasal CSF leak repair with SES placed as part of the bolster technique at a tertiary care center between January 2019 and May 2022. Age, sex, BMI, comorbid idiopathic intracranial hypertension, pathology, location of CSF leak, intraoperative CSF leak flow, reconstruction type, and presence of post-op CSF leak were recorded.

resultsTwelve patients (mean age 52, median BMI 30.9, 58% female) had SES placement as part of the bolster technique. The most common pathology was meningoencephalocele (75%). Reconstruction was performed with either a free mucosal graft (6), or a flap (6). No post-op CSF leaks occurred at a reconstruction site with a stent, and no known complications were reported. All sinusotomies were patent at the last follow-up visit.

conclusionsSES placement as an adjunct to graft and/or flap bolster appears to be safe and feasible during anterior skull base reconstruction and CSF leak repair providing longer term structural support and preserving sinus drainage patency.

Indexed as

Drug-Eluting StentsPlastic Surgery ProceduresCerebrospinal Fluid LeakEndoscopyFeasibility StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesSkull BaseSurgical FlapsCSF leakCSF rhinorrheafunctional endoscopic endonasal sinus surgeryidiopathic intracranial hypertensionskull base reconstructionsteroid eluting stent

Identifiers

PMID37334915
PMCPMC11407796
OpenAlexW4381164739

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.