Evidence map›Paper›PMID 37334790›Full record

ArticleGM crops & food2023

Safety Assessment of the CP4 EPSPS and NPTII Proteins in Eucalyptus.

Dror Avisar, Shelly Azulay, Lorena Bombonato, Denise Carvalho, Heitor Dallapicolla, Carla de Souza, Anselmo Dos Santos, Tatiane Dias, Maria Paula Galan, Milton Galvao and 15 more

Open access · goldAbstract read
In one paragraph

Article in GM crops & food, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Genetically engineered eucalyptus expressing pesticidal proteins fromFrontiers in bioengineering and biotechnology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 2 institutions in 2 countries.

Dror AvisarR&D, FuturaGene Israel Ltd, Rehovot, Israel.ORCID 0009-0008-6664-0824
Shelly AzulayR&D, FuturaGene Israel Ltd, Rehovot, Israel.ORCID 0009-0004-6139-1874
Lorena BombonatoSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0005-3048-0628
Denise CarvalhoSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0001-2438-9087
Heitor DallapicollaSuzano S.A. (Forest Management), SP, Brazil.ORCID 0000-0002-1519-0199
Carla de SouzaSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0003-6329-742X
Anselmo Dos SantosSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0007-3564-0162
Tatiane DiasSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0007-1568-3632
Maria Paula GalanSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0001-6659-9816
Milton GalvaoSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0002-6246-7688
José Mateus GonsalvesSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0000-0003-0482-3189
Esteban GonzalesSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0009-4305-1602
Rodrigo GraçaSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0007-3395-2859
Sivan LivneR&D, FuturaGene Israel Ltd, Rehovot, Israel.ORCID 0000-0001-7973-4944
Reginaldo MafiaSuzano S.A. (Forest Management), SP, Brazil.ORCID 0000-0003-2408-5531
Alexandre ManoeliSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0006-5561-0107
Mike MayR&D, FuturaGene Israel Ltd, Rehovot, Israel.ORCID 0000-0001-7082-1582
Thaís Regina Drezza MenezesSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0000-0002-5608-5678
Ana Cristina PinheiroSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0000-0002-8778-7234
Antonio PortoSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0000-0002-8229-0149
Carolina RochaSuzano S.A. (FuturaGene - Biotech Division), Itapetininga, Brazil.ORCID 0009-0004-9196-9534
Ariane SchaferSchafer Scientific Solutions LLC, Indianapolis, USA.ORCID 0009-0007-3281-6775
Barry SchaferSchafer Scientific Solutions LLC, Indianapolis, USA.ORCID 0000-0002-2960-8330
Edival ZauzaSuzano S.A. (Forest Management), SP, Brazil.ORCID 0000-0001-8322-7689
William SilvaW J Silva Consultoria Agricola S/C LTDA, Jardinópolis, Brazil.ORCID 0009-0006-3782-1031
Suzano (Brazil) · BRScientific Solutions (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glyphosate herbicide treatment is essential to sustainable Eucalyptus plantation management in Brazil. Eucalyptus is highly sensitive to glyphosate, and Suzano/FuturaGene has genetically modified eucalyptus to tolerate glyphosate, with the aim of both protecting eucalyptus trees from glyphosate application damage and improving weed management. This study presents the biosafety results of the glyphosate-tolerant eucalyptus event 751K032, which expresses the selection marker neomycin phosphotransferase II (NPTII) enzyme and CP4-EPSPS, a glyphosate-tolerant variant of plant 5-enolpyruvyl-shikimate-3-phosphate synthase enzyme. The transgenic genetically modified (GM) event 751K032 behaved in the plantations like conventional non-transgenic eucalyptus clone, FGN-K, and had no effects on arthropods and soil microorganisms. The engineered NPTII and CP4 EPSPS proteins were heat-labile, readily digestible, and according to the bioinformatics analyses, unlikely to cause an allergenic or toxic reaction in humans or animals. This assessment of the biosafety of the glyphosate-tolerant eucalyptus event 751K032 concludes that it is safe to be used for wood production.

Indexed as

EucalyptusHerbicidesAnimalsHumansKanamycin KinasePlants, Genetically ModifiedShikimic AcidHerbicidesKanamycin KinaseshikimateShikimic AcidCP4-EPSPSeucalyptusgenetically modifiedglyphosate-tolerancesaftey assesments

Identifiers

PMID37334790
PMCPMC10281460
OpenAlexW4381308519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.