Evidence map›Paper›PMID 37334305›Full record

ArticleFrontiers in endocrinology2023

Heritability and circulating concentrations of pregnancy-associated plasma protein-A and stanniocalcin-2 in elderly monozygotic and dizygotic twins.

Rikke Hjortebjerg, Dorthe Almind Pedersen, Jonas Mengel-From, Louise Helskov Jørgensen, Kaare Christensen, Jan Frystyk

Open access · goldAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rikke HjortebjergEndocrine Research Unit, Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Dorthe Almind PedersenThe Danish Twin Registry and Danish Aging Research Center, University of Southern Denmark, Odense, Denmark.
Jonas Mengel-FromThe Danish Twin Registry and Danish Aging Research Center, University of Southern Denmark, Odense, Denmark.
Louise Helskov JørgensenDepartment of Biochemistry, Odense University Hospital, Odense, Denmark.
Kaare ChristensenThe Danish Twin Registry and Danish Aging Research Center, University of Southern Denmark, Odense, Denmark.
Jan FrystykEndocrine Research Unit, Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Odense University Hospital · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Pregnancy-associated plasma protein-A (PAPP-A) is an IGF-activating enzyme suggested to influence aging-related diseases. However, knowledge on serum PAPP-A concentration and regulation in elderly subjects is limited. Therefore, we measured serum PAPP-A in elderly same-sex monozygotic (MZ) and dizygotic (DZ) twins, as this allowed us to describe the age-relationship of PAPP-A, and to test the hypothesis that serum PAPP-A concentrations are genetically determined. As PAPP-A is functionally related to stanniocalcin-2 (STC2), an endogenous PAPP-A inhibitor, we included measurements on STC2 as well as IGF-I and IGF-II. Methods: The twin cohort contained 596 subjects (250 MZ twins, 346 DZ twins), whereof 33% were males. The age ranged from 73.2 to 94.3 (mean 78.8) years. Serum was analyzed for PAPP-A, STC2, IGF-I, and IGF-II by commercial immunoassays. Results: In the twin cohort, PAPP-A increased with age (r=0.19; Discussion: This twin study confirms our hypothesis that the heritability of PAPP-A serum concentrations is substantial, and the same is true for STC2. As regards the age relationship, PAPP-A increases with age, whereas STC2 remains unchanged, thereby supporting the idea that the ability of STC2 to inhibit PAPP-A enzymatic activity decreases with increasing age.

Indexed as

Insulin-Like Growth Factor IPeptide HormonesAgedAged, 80 and overFemaleGlycoproteinsHumansInsulin-Like Growth Factor IIMalePregnancy-Associated Plasma Protein-ATwins, DizygoticGlycoproteinsInsulin-Like Growth Factor IInsulin-Like Growth Factor IIPeptide HormonesPregnancy-Associated Plasma Protein-AteleocalcinagingIGF-IIGF-IIPAPP-ASTC2twin

Identifiers

PMID37334305
PMCPMC10272750
OpenAlexW4379229303

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.