Evidence map›Paper›PMID 37334257›Full record

ArticleNeurology. Genetics2023

Systemic Capillary Leak Syndrome With Cerebral Involvement in a

Stefan Sennfält, Oskar Aspegren, Martin Engvall, Tobias Granberg, Fredrik Piehl

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Erratum: Missing Full Disclosures.Neurology. Genetics · 2024
    Article
  3. Systemic capillary leak syndrome.Nature reviews. Disease primers · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Stefan SennfältFrom the Department of Clinical Neuroscience (S.S., T.G., F.P.), Karolinska Institutet; Department of Neurology (S.S., F.P.); Department of Pathology and Cancer Diagnostics (O.A.), Karolinska University Hospital; Department of Oncology-Pathology (O.A.); Department of Molecular Medicine and Surgery (M.E.), Karolinska Institutet; Center for Inherited Metabolic Diseases (M.E.); and Department of Neuroradiology (T.G.), Karolinska University Hospital, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-7114-2757
Oskar AspegrenFrom the Department of Clinical Neuroscience (S.S., T.G., F.P.), Karolinska Institutet; Department of Neurology (S.S., F.P.); Department of Pathology and Cancer Diagnostics (O.A.), Karolinska University Hospital; Department of Oncology-Pathology (O.A.); Department of Molecular Medicine and Surgery (M.E.), Karolinska Institutet; Center for Inherited Metabolic Diseases (M.E.); and Department of Neuroradiology (T.G.), Karolinska University Hospital, Stockholm, Sweden.
Martin EngvallFrom the Department of Clinical Neuroscience (S.S., T.G., F.P.), Karolinska Institutet; Department of Neurology (S.S., F.P.); Department of Pathology and Cancer Diagnostics (O.A.), Karolinska University Hospital; Department of Oncology-Pathology (O.A.); Department of Molecular Medicine and Surgery (M.E.), Karolinska Institutet; Center for Inherited Metabolic Diseases (M.E.); and Department of Neuroradiology (T.G.), Karolinska University Hospital, Stockholm, Sweden.
Tobias GranbergFrom the Department of Clinical Neuroscience (S.S., T.G., F.P.), Karolinska Institutet; Department of Neurology (S.S., F.P.); Department of Pathology and Cancer Diagnostics (O.A.), Karolinska University Hospital; Department of Oncology-Pathology (O.A.); Department of Molecular Medicine and Surgery (M.E.), Karolinska Institutet; Center for Inherited Metabolic Diseases (M.E.); and Department of Neuroradiology (T.G.), Karolinska University Hospital, Stockholm, Sweden.
Fredrik PiehlFrom the Department of Clinical Neuroscience (S.S., T.G., F.P.), Karolinska Institutet; Department of Neurology (S.S., F.P.); Department of Pathology and Cancer Diagnostics (O.A.), Karolinska University Hospital; Department of Oncology-Pathology (O.A.); Department of Molecular Medicine and Surgery (M.E.), Karolinska Institutet; Center for Inherited Metabolic Diseases (M.E.); and Department of Neuroradiology (T.G.), Karolinska University Hospital, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-8329-5219
Karolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Systemic capillary leak syndrome (SCLS) is a rare condition associated with episodes of hypotension, hemoconcentration, hypoalbuminemia, and rhabdomyolysis. We describe a middle-aged man presenting with several distinct SCLS-like episodes, the last being fatal. In addition, in the year before the final event, he developed rapid cognitive decline with contrast-enhancing lesions on MRI and highly elevated neurofilament light protein levels in CSF. Methods: Data and imaging were obtained from patient medical records. Results: At the time, the SCLS-like episodes were interpreted as myositis secondary to viral infection. A thorough workup for other causes, including genetic testing, was negative. As for the rapid cognitive decline, despite an extensive workup for infectious and inflammatory causes, no definitive diagnosis was made. Whole genome sequencing however identified a Discussion: The

Identifiers

PMID37334257
PMCPMC10275405
OpenAlexW4380569323

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.