Evidence map›Paper›PMID 37334224›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2023

Hypokinetic Activity of Menthofuran on the Gastrointestinal Tract in Rodents.

Railson de Sousa Santos, Paulo Humberto Moreira Nunes, Geovanni de Morais Lima, Ana Karolinne da Silva Brito, James Frederico Rocha Pacheco, Heldemys da Costa Medina, Maria Ivone Mendes Benigno, Damião Pergentino de Sousa, Oseas Florêncio de Moura-Filho, Francisco Valmor Macedo Cunha and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Investigating the Health Potential ofPharmaceuticals (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Railson de Sousa SantosDepartment of Biophysics and Physiology, Federal University of Piauí, PI, Teresina, Brazil.ORCID https://orcid.org/0009-0003-3489-6888
Paulo Humberto Moreira NunesDepartment of Biophysics and Physiology, Federal University of Piauí, PI, Teresina, Brazil.ORCID https://orcid.org/0000-0001-9507-9337
Geovanni de Morais LimaDepartment of Biophysics and Physiology, Federal University of Piauí, PI, Teresina, Brazil.ORCID https://orcid.org/0000-0002-7681-6669
Ana Karolinne da Silva BritoDepartment of Biophysics and Physiology, Federal University of Piauí, PI, Teresina, Brazil.ORCID https://orcid.org/0000-0002-9575-2103
James Frederico Rocha PachecoDepartment of Biophysics and Physiology, Federal University of Piauí, PI, Teresina, Brazil.ORCID https://orcid.org/0000-0001-7524-6193
Heldemys da Costa MedinaDepartment of Biophysics and Physiology, Federal University of Piauí, PI, Teresina, Brazil.ORCID https://orcid.org/0009-0001-8891-3909
Maria Ivone Mendes BenignoDepartment of Morphology, Federal University of Piauí, PI, Teresina, Brazil.ORCID https://orcid.org/0000-0002-6736-9246
Damião Pergentino de SousaDepartment of Pharmaceutical Sciences, Federal University of Paraíba, PB, João Pessoa, Brazil.ORCID https://orcid.org/0000-0002-7180-4896
Oseas Florêncio de Moura-FilhoPhysios-Functional Health Clinic Ltd., Piauí, Teresina, Brazil.ORCID https://orcid.org/0000-0002-9723-4000
Francisco Valmor Macedo CunhaUninovafapi University Centre, PI, Teresina, Brazil.ORCID https://orcid.org/0000-0001-7927-7747
Renandro de Carvalho ReisUninovafapi University Centre, PI, Teresina, Brazil.ORCID https://orcid.org/0000-0002-3194-9767
Rita de Cássia Meneses OliveiraDepartment of Biophysics and Physiology, Federal University of Piauí, PI, Teresina, Brazil.ORCID https://orcid.org/0000-0003-1669-4628
Daniel Dias Rufino ArcanjoDepartment of Biophysics and Physiology, Federal University of Piauí, PI, Teresina, Brazil.ORCID https://orcid.org/0000-0001-7021-2744
Maria do Carmo de Carvalho E MartinsDepartment of Biophysics and Physiology, Federal University of Piauí, PI, Teresina, Brazil.ORCID https://orcid.org/0000-0002-9107-2485
Universidade Federal do Piauí · BRCentro Universitário UNINOVAFAPI · BRUniversidade Federal da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The acute toxicity and hypokinetic activity induced by menthofuran on the gastrointestinal tract of rodents were investigated in the present study. An absence of acute toxicity was observed. Menthofuran delayed gastric emptying at oral doses of 25, 50, and 100 mg/kg in the experimental model of phenol red, as well as it reduced the intestinal transit at oral doses of 50 and 100 mg/kg. Interestingly, a scopolamine-similar hypokinetic effect was observed for menthofuran. In the experimental model of castor oil-induced intestinal hypermotility, menthofuran (50 and 100 mg/kg) reduced the number of loose stools as observed for the normal group. Additionally, menthofuran induced a marked concentration-dependent relaxation in rat ileum segments precontracted with KCl (EC

Identifiers

PMID37334224
PMCPMC10276764
OpenAlexW4380267237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.