Evidence map›Paper›PMID 37334209›Full record

ArticleJournal of biomedical optics2023

Enhanced neuroimaging with a calcium sensor in

Antoine Hubert, Georges Farkouh, Fabrice Harms, Cynthia Veilly, Sophia Imperato, Mathias Mercier, Vincent Loriette, François Rouyer, Alexandra Fragola

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical optics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Imaging Cell Competition in Ex-VivoMethods and protocols · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 2 countries.

Antoine HubertSorbonne Université, PSL Research University, CNRS, Laboratoire Physique et Etudes des Matériaux, ESPCI Paris, Paris, France.ORCID 0000-0002-1742-8877
Georges FarkouhUniversité de Paris, CNRS, Institut Jacques Monod, Paris, France.ORCID 0000-0003-2552-9923
Fabrice HarmsImagine Optic, Orsay, France.ORCID 0000-0002-6652-5219
Cynthia VeillyImagine Optic, Orsay, France.
Sophia ImperatoSorbonne Université, PSL Research University, CNRS, Laboratoire Physique et Etudes des Matériaux, ESPCI Paris, Paris, France.
Mathias MercierSorbonne Université, PSL Research University, CNRS, Laboratoire Physique et Etudes des Matériaux, ESPCI Paris, Paris, France.
Vincent LorietteSorbonne Université, PSL Research University, CNRS, Laboratoire Physique et Etudes des Matériaux, ESPCI Paris, Paris, France.ORCID 0000-0002-4551-2902
François RouyerUniversité Paris Saclay, Institut des Neurosciences Paris-Saclay, CNRS, Saclay, France.ORCID 0000-0001-5641-397X
Alexandra FragolaUniversité Paris-Saclay, Institut des Sciences Moléculaires d'Orsay, CNRS, Orsay, France.ORCID 0000-0001-8481-3516
Imagine Optic (France) · FRCentre National de la Recherche Scientifique · FRESPCI Paris · FRInstitut des Neurosciences Paris-Saclay · FRSorbonne Université · FRUniversité Paris-Saclay · FRUniversité Paris Sciences et Lettres · FRZero to Three · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significance: Adaptive optics (AO) has been implemented on several microscopy setups and has proven its ability to increase both signal and resolution. However, reported configurations are not suited for fast imaging of live samples or are based on an invasive or complex implementation method. Aim: Provide a fast aberration correction method with an easy to implement AO module compatible with light-sheet fluorescence microscopy (LSFM) for enhanced imaging of live samples. Approach: Development of an AO add-on module for LSFM based on direct wavefront sensing without requiring a guide star using an extended-scene Shack-Hartmann wavefront sensor. The enhanced setup uses a two-color sample labeling strategy to optimize the photon budget. Results: Fast AO correction of in-depth aberrations in an Conclusion: We developed a compact AO module that can be integrated into most of the reported light-sheet microscopy setups, provides significant improvement of image quality and is compatible with fast imaging requirements such as calcium imaging.

Indexed as

CalciumDrosophila melanogasterAnimalsBrainDrosophilaMicroscopy, FluorescenceNeuroimagingCalciumadaptive opticsDrosophila brainlight-sheet microscopyneuroimaging

Identifiers

PMID37334209
PMCPMC10275380
OpenAlexW4380987022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.