Evidence map›Paper›PMID 37333724›Full record

ArticleOpen forum infectious diseases2023

Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea.

Frank B Williams, Md Abdul Kader, Dorothy M Dickson, E Ross Colgate, Masud Alam, Rashidul Haque, William A Petri, Beth D Kirkpatrick, Benjamin Lee

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07615842 (Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07615842 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants

TypeinterventionalSponsorUniversity of VirginiaRan2026 to 2028Enrolled150ConditionsAntibiotic Resistance PreventionArmsAzithromycin
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Frank B WilliamsVaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Md Abdul KaderInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Dorothy M DicksonVaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
E Ross ColgateVaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Masud AlamInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Rashidul HaqueInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
William A PetriDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-7268-1218
Beth D KirkpatrickVaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Benjamin LeeVaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.ORCID https://orcid.org/0000-0001-7213-5631
University of Vermont · USInternational Centre for Diarrhoeal Disease Research · BDUniversity of Virginia · US

Funding

Using Dengue Controlled Human Infection Model to Identify Adaptive Immune Correlates of ProtectionP20GM125498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Ellen Kozelka · 2018 to 2026
$24.9M
FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
NIAID NIH HHS R01 AI043596NIGMS NIH HHS P20 GM125498
6 · The paper itself

Abstract

Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact on risk of infant rotavirus diarrhea or vaccine efficacy through 2 years of life, underscoring limitations of immunogenicity assessment alone in evaluation of oral rotavirus vaccine response.

Indexed as

breast milkoral vaccinationrotavirussecretor status

Identifiers

PMID37333724
PMCPMC10270652
OpenAlexW4379742460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.