Evidence map›Paper›PMID 37333613›Full record

ArticleNAR cancer2023

DICER1 platform domain missense variants inhibit miRNA biogenesis and lead to tumor susceptibility.

Dylan Pelletier, Anne-Laure Chong, Mona Wu, Leora Witkowski, Sophie Albert, Nelly Sabbaghian, Marc R Fabian, William D Foulkes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Dylan PelletierDepartment of Human Genetics, Medicine, McGill University, Montreal, QC, Canada.
Anne-Laure ChongDepartment of Human Genetics, Medicine, McGill University, Montreal, QC, Canada.
Mona WuDepartment of Human Genetics, Medicine, McGill University, Montreal, QC, Canada.
Leora WitkowskiDepartment of Human Genetics, Medicine, McGill University, Montreal, QC, Canada.
Sophie AlbertCancer Axis, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
Nelly SabbaghianDepartment of Human Genetics, Medicine, McGill University, Montreal, QC, Canada.
Marc R FabianCancer Axis, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.ORCID https://orcid.org/0000-0003-3700-7604
William D FoulkesDepartment of Human Genetics, Medicine, McGill University, Montreal, QC, Canada.ORCID https://orcid.org/0000-0001-7427-4651
Jewish General Hospital · CAMcGill University · CAMcGill University Health Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endoribonuclease DICER1 plays an essential role in the microRNA (miRNA) biogenesis pathway, cleaving precursor miRNA (pre-miRNA) stem-loops to generate mature single-stranded miRNAs. Germline pathogenic variants (GPVs) in

Identifiers

PMID37333613
PMCPMC10273190
OpenAlexW4381089891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.