ArticleCanadian journal of kidney health and disease2023
The Impact of Combined Warm and Cold Ischemia Time on Post-transplant Outcomes.
Article in Canadian journal of kidney health and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Construction and validation of a prediction model for graft failure in pediatric liver transplant recipients based on the APRI-ALBI score: a retrospective study of 289 cases.Annals of medicine · 2026Article
- Impact of pretransplant donor-specific antibodies and human leukocyte antigen mismatches on graft and patient outcomes: A cohort from Saudi Arabia.World journal of transplantation · 2026Article
- Beyond living donation: robot-assisted kidney transplantation using deceased-donor grafts-a scoping review of selection, ischaemia logistics, and allograft outcomes.Journal of robotic surgery · 2026Article
- Characterizing Early Donor-Derived cfDNA Kinetics in Stable Pediatric Living-Donor Liver Transplant Recipients.Pediatric transplantation · 2026Article
- Feasibility of simultaneous donor nephrectomy and kidney transplantation using a shared single-port robotic platform.Journal of robotic surgery · 2026Article
- Comparison of Plastic, Fully Covered Metal, and Intraductal Metal Stents for Biliary Anastomotic Strictures After Living Donor Liver Transplantation: A Single-Center Experience.Journal of clinical medicine · 2026Article
- Review
- Diagnosis of early kidney allograft rejection: influencing factors in metabolite-based urine analysis.Frontiers in medicine · 2026Article
- The effect of cold ischemia time on hypoxia, EMT, and apoptosis pathways in normal colon mucosa.PloS one · 2026Article
- Soluble Thrombomodulin as a Marker of Endothelial Injury in Early Post-Transplant Period: A Comparative Study of Simple Hypothermia and Pulsatile Machine Perfusion in Kidney Graft Preservation.Journal of clinical medicine · 2025Article
- Robot-assisted Kidney Transplantation from Deceased Donor: The European Experience.European urology open science · 2025Article
- Risk Factors for Perioperative Urinary Tract Infection After Living Donor Kidney Transplantation Characterized by High Prevalence of Desensitization Therapy: A Single-Center Analysis.Journal of clinical medicine · 2025Article
- Angiotensin II type 1 receptor antibodies as a contributor to microvascular inflammation in kidney transplant recipients: insights from statistical and artificial intelligence based approaches.Frontiers in immunology · 2025Article
- Donor Characteristics Associated With Graft Loss and Delayed Graft Function in Very-Aged Kidney Donors: An Observational Multicentric Study.Transplant international : official journal of the European Society for Organ Transplantation · 2025Observational
- Right Versus Left Laparoscopic Donor Nephrectomy and Its Effects on Transplant Outcomes: Experience From Saudi Arabia.Journal of transplantation · 2025Article
- Evaluating Graft Loss Risk in Living-Donor Kidney Transplants with Multiple Renal Arteries.Annals of transplantation · 2024Article
- Solid organ transplantation originating from uncontrolled donation after circulatory death in Europe: a narrative review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Review
- Pre-transplant kidney quality evaluation using photoacoustic imaging during normothermic machine perfusion.Photoacoustics · 2024Article
- Promising Results of Kidney Transplantation From Donors Following Euthanasia During 10-Year Follow-Up: A Nationwide Cohort Study.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Antegrade persufflation of porcine kidneys improves renal function after warm ischemia.Frontiers in transplantation · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Prolonged warm ischemia time (WIT) and cold ischemia time (CIT) are independently associated with post-transplant graft failure; their combined impact has not been previously studied. We explored the effect of combined WIT/CIT on all-cause graft failure following kidney transplantation. Methods: The Scientific Registry of Transplant Recipients was used to identify kidney transplant recipients from January 2000 to March 2015 (after which WIT was no longer separately reported), and patients were followed until September 2017. A combined WIT/CIT variable (excluding extreme values) was separately derived for live and deceased donor recipients using cubic splines; for live donor recipients, the reference group was WIT 10 to <23 minutes and CIT >0 to <0.42 hours, and for deceased donor recipients the WIT was 10 to <25 minutes and CIT 1 to <7.75 hours. The adjusted association between combined WIT/CIT and all-cause graft failure (including death) was analyzed using Cox regression. Secondary outcomes included delayed graft function (DGF). Results: A total of 137 125 recipients were included. For live donor recipients, patients with prolonged WIT/CIT (60 to ≤120 minutes/3.04 to ≤24 hours) had the highest adjusted hazard ratio (HR) for graft failure (HR = 1.61, 95% confidence interval [CI] = 1.14-2.29 relative to the reference group). For deceased donor recipients, a WIT/CIT of 63 to ≤120 minutes/28 to ≤48 hours was associated with an adjusted HR of 1.35 (95% CI = 1.16-1.58). Prolonged WIT/CIT was also associated with DGF for both groups although the impact was more driven by CIT. Conclusions: Combined WIT/CIT is associated with graft loss following transplantation. Acknowledging that these are separate variables with different determinants, we emphasize the importance of capturing WIT and CIT independently. Furthermore, efforts to reduce WIT and CIT should be prioritized.
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