Evidence map›Paper›PMID 37333407›Full record

ArticlebioRxiv : the preprint server for biology2023

Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory.

Claire C Chen, Joseph Han, Carlene A Chinn, Jacob S Rounds, Xiang Li, Mehran Nikan, Marie Myszka, Liqi Tong, Luiz F M Passalacqua, Timothy W Bredy and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Claire C ChenDepartment of Pharmaceutical Sciences, University of California-Irvine, Irvine, California 92697, United States.
Joseph HanDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California-Irvine, Irvine, California 92697, United States.
Carlene A ChinnDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California-Irvine, Irvine, California 92697, United States.
Jacob S RoundsDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California-Irvine, Irvine, California 92697, United States.
Xiang LiDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California-Irvine, Irvine, California 92697, United States.
Mehran NikanIonis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Marie MyszkaDepartment of Chemistry, University of California-Irvine, Irvine, California 92697, United States.
Liqi TongInstitute for Memory Impairments and Neurological Disorders, University of California-Irvine, Irvine, California 92697, United States.
Luiz F M PassalacquaDepartment of Pharmaceutical Sciences, University of California-Irvine, Irvine, California 92697, United States.
Timothy W BredyDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California-Irvine, Irvine, California 92697, United States.
Marcelo A WoodDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California-Irvine, Irvine, California 92697, United States.
Andrej LuptákDepartment of Pharmaceutical Sciences, University of California-Irvine, Irvine, California 92697, United States.
University of California, Irvine · USIonis Pharmaceuticals (United States) · US

Funding

Epigenetic suppression of histone methylation reverses age and AD-related cognitive declineRF1AG057558 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2018 to 2018
$3.8M
Exercise-induced epigenetic mechanisms underlying neuronal plasticity and cognitionR01AG051807 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI COTMAN, CARL WAYNE, WOOD, MARCELO ANDRES · 2016 to 2020
$3.1M
Role of UHRF1 in osteosarcoma metastasisR01CA229696 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENAVENTE, CLAUDIA ANDREA · 2019 to 2023
$2.4M
NCI NIH HHS R01 CA229696NIA NIH HHS R01 AG051807NIA NIH HHS RF1 AG057558
6 · The paper itself

Abstract

A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element binding protein 3 (

Identifiers

PMID37333407
PMCPMC10274809
OpenAlexW4380079383

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.