Evidence map›Paper›PMID 37333381›Full record

ArticlebioRxiv : the preprint server for biology2023

A non-oscillatory, millisecond-scale embedding of brain state provides insight into behavior.

David F Parks, Aidan M Schneider, Yifan Xu, Samuel J Brunwasser, Samuel Funderburk, Danilo Thurber, Tim Blanche, Eva L Dyer, David Haussler, Keith B Hengen

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

David F ParksDepartment of Biomolecular Engineering, University of California, Santa Cruz.
Aidan M SchneiderDepartment of Biology, Washington University in Saint Louis.
Yifan XuDepartment of Biology, Washington University in Saint Louis.
Samuel J BrunwasserDepartment of Biology, Washington University in Saint Louis.
Samuel FunderburkDepartment of Biology, Washington University in Saint Louis.
Danilo ThurberExeter, NH.
Tim BlancheWhite Matter LLC, Seattle, WA.
Eva L DyerDepartment of Biomedical Engineering, Georgia Tech, Atlanta GA.
David HausslerDepartment of Biomolecular Engineering, University of California, Santa Cruz.
Keith B HengenDepartment of Biology, Washington University in Saint Louis.
Washington University in St. Louis · USUniversity of California, Santa Cruz · USGeorgia Institute of Technology · USPhillips Exeter Academy · USThe White House · US

Funding

Robust circuit computation in freely behaving animals.RF1NS118442 · NINDS · WASHINGTON UNIVERSITY · PI HENGEN, KEITH B. · 2020 to 2020
$1.8M
Robust circuit computation in freely behaving animals.R01NS118442 · NINDS · WASHINGTON UNIVERSITY · PI HENGEN, KEITH B. · 2023 to 2024
$1.0M
NINDS NIH HHS R01 NS118442NINDS NIH HHS RF1 NS118442
6 · The paper itself

Abstract

Sleep and wake are understood to be slow, long-lasting processes that span the entire brain. Brain states correlate with many neurophysiological changes, yet the most robust and reliable signature of state is enriched in rhythms between 0.1 and 20 Hz. The possibility that the fundamental unit of brain state could be a reliable structure at the scale of milliseconds and microns has not been addressed due to the physical limits associated with oscillation-based definitions. Here, by analyzing high resolution neural activity recorded in 10 anatomically and functionally diverse regions of the murine brain over 24 h, we reveal a mechanistically distinct embedding of state in the brain. Sleep and wake states can be accurately classified from on the order of 10

Identifiers

PMID37333381
PMCPMC10274881
OpenAlexW4380033652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.