Evidence map›Paper›PMID 37333374›Full record

ArticlebioRxiv : the preprint server for biology2023

Site-Specific Phosphorylation of ZYG-1 Regulates ZYG-1 Stability and Centrosome Number.

Jeffrey C Medley, Nahyun Yim, Joseph DiPanni, Brandon Sebou, Blake Shaffou, Evan Cramer, Colin Wu, Megan Kabara, Mi Hye Song

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jeffrey C MedleyDepartment of Biological Sciences, Oakland University, MI, USA.
Nahyun YimDepartment of Biological Sciences, Oakland University, MI, USA.
Joseph DiPanniDepartment of Biological Sciences, Oakland University, MI, USA.
Brandon SebouDepartment of Biological Sciences, Oakland University, MI, USA.
Blake ShaffouDepartment of Biological Sciences, Oakland University, MI, USA.
Evan CramerDepartment of Chemistry, Oakland University, MI, USA.
Colin WuDepartment of Chemistry, Oakland University, MI, USA.
Megan KabaraDepartment of Biological Sciences, Oakland University, MI, USA.
Mi Hye SongDepartment of Biological Sciences, Oakland University, MI, USA.
Oakland University · USUniversity of Connecticut · US

Funding

Proteolytic Regulation of Centrosome AssemblyR15GM147857 · NIGMS · OAKLAND UNIVERSITY · PI SONG, MI HYE · 2022 to 2024
$563k
Centrosome Regulation by Proteolysis in C. elegansR15GM128110 · NIGMS · OAKLAND UNIVERSITY · PI SONG, MI HYE · 2018 to 2018
$443k
NIGMS NIH HHS R15 GM128110NIGMS NIH HHS R15 GM147857
6 · The paper itself

Abstract

Spindle bipolarity is critical for genomic integrity. Given that centrosome number often dictates mitotic bipolarity, tight control of centrosome assembly is vital for the fidelity of cell division. The kinase ZYG-1/Plk4 is a master centrosome factor that is integral for controlling centrosome number and is modulated by protein phosphorylation. While autophosphorylation of Plk4 has been extensively studied in other systems, the mechanism of ZYG-1 phosphorylation in

Indexed as

Casein Kinase IIC. elegansCentrosomeCK2PhosphorylationProteolysisZYG-1

Identifiers

PMID37333374
PMCPMC10274923
OpenAlexW4375867258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.