Evidence map›Paper›PMID 37333274›Full record

ArticlebioRxiv : the preprint server for biology2023

Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.

Yi-Ju Tseng, Indranil Malik, Xiexiong Deng, Amy Krans, Karen Jansen-West, Elizabeth M H Tank, Nicolas B Gomez, Roger Sher, Leonard Petrucelli, Sami J Barmada and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yi-Ju TsengCellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.
Indranil MalikDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA.
Xiexiong DengDepartment of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, 48109, USA.
Amy KransDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA.
Karen Jansen-WestDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Elizabeth M H TankDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA.
Nicolas B GomezCellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.
Roger SherDepartment of Neurobiology and Behavior & Center for Nervous System Disorders, Stony Brook University, Stony Brook, NY, 11794, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Sami J BarmadaCellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.
Peter K ToddCellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.
University of Michigan · USMayo Clinic in Florida · USHoward Hughes Medical Institute · USStony Brook University · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Research Education ComponentP30AG072931 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 2021 to 2026
$26.5M
Project 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6M
Expanding insights into FTD disease mechanismsR35NS097273 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2017 to 2024
$10.6M
The FMR1 CGG repeat as functional element and therapeutic target in Fragile X associated disordersP50HD104463 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN · 2020 to 2024
$9.0M
Hexanucleotide repeat translation in ALS and Frontotemporal DementiaR01NS099280 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter K Todd · 2016 to 2026
$4.9M
CGG repeat associated translation in Fragile X-associated Tremor/Ataxia Syndrome-Diversity SupplementR01NS086810 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TODD, PETER K · 2014 to 2024
$4.1M
Novel genetic modifiers of C9orf72 and Tau toxicityRF1AG062077 · NIA · MAYO CLINIC ARIZONA · PI FRYER, JOHN DAVID, PETRUCELLI, LEONARD · 2019 to 2019
$4.0M
RNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degenerationR01NS097542 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2016 to 2025
$3.8M
Nuclear Pore Complex and as a Contributor to Tau Associated DementiaRF1AG062171 · NIA · JOHNS HOPKINS UNIVERSITY · PI PETRUCELLI, LEONARD, ROTHSTEIN, JEFFREY D · 2019 to 2019
$3.8M
Atypical TDP43 isoforrms driving neurodegeneration in FTD/ALSR01NS113943 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2020 to 2024
$1.9M
Spatiotemporal analysis of TDP-43 toxicity and endolysosomal turnover mechanismsR56NS128110 · NINDS · UNIVERSITY OF ARIZONA · PI BARMADA, SAMI, BUCHAN, JOHN ROSS · 2022 to 2022
$393k
BLRD VA I01 BX004842NIA NIH HHS P30 AG072931NIA NIH HHS RF1 AG062077NIA NIH HHS RF1 AG062171NICHD NIH HHS P50 HD104463NIGMS NIH HHS T32 GM007863NINDS NIH HHS P01 NS084974NINDS NIH HHS R01 NS086810NINDS NIH HHS R01 NS097542NINDS NIH HHS R01 NS099280NINDS NIH HHS R01 NS113943NINDS NIH HHS R35 NS097273NINDS NIH HHS R56 NS128110
6 · The paper itself

Abstract

A GGGGCC (G4C2) hexanucleotide repeat expansion in

Identifiers

PMID37333274
PMCPMC10274811
OpenAlexW4379883574

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.