Evidence map›Paper›PMID 37333273›Full record

ArticlebioRxiv : the preprint server for biology2023

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway.

Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Jason Swinderman, Feiqiao B Yu, Xuchao Lyu, Gemini Skariah, Vishvak Subramanyam, Luke A Gilbert and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Songnan WangDepartment of Biochemistry, Stanford University, Stanford 94305, USA.
Volker BöhnertDepartment of Biochemistry, Stanford University, Stanford 94305, USA.
Alby J JosephDepartment of Biochemistry, Stanford University, Stanford 94305, USA.
Valentino SudaryoDepartment of Biochemistry, Stanford University, Stanford 94305, USA.
Jason SwindermanArc Institute, Palo Alto 94304, USA.
Feiqiao B YuArc Institute, Palo Alto 94304, USA.
Xuchao LyuChEM-H Institute, Stanford University, Stanford 94305, USA.
Gemini SkariahDepartment of Biochemistry, Stanford University, Stanford 94305, USA.
Vishvak SubramanyamDepartment of Urology, University of California, San Francisco, San Francisco 94143, USA.
Luke A GilbertArc Institute, Palo Alto 94304, USA.
Hani GoodarziDepartment of Urology, University of California, San Francisco, San Francisco 94143, USA.
Li LingyinDepartment of Biochemistry, Stanford University, Stanford 94305, USA.
Palo Alto Institute · USUniversity of California, San Francisco · USStanford University · US

Funding

The I SPY 2.2 TRIAL: Evolving to Imaging and Molecular Biomarker Response Directed Adaptive Sequential Treatment to Optimize Breast Cancer OutcomesP01CA210961 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAURA J ESSERMAN · 2017 to 2026
$22.9M
Investigating the roles of extracellular cGAMP and harnessing it for cancer treatmentR01CA258427 · NCI · STANFORD UNIVERSITY · PI STRAIGHT, AARON F · 2021 to 2025
$2.5M
A GENETIC INTERACTION MAP OF THE HUMAN NUCLEUSDP2CA239597 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GILBERT, LUKE · 2018 to 2018
$2.4M
Chemical biology of innate immunity for treating cancer and autoimmunityDP2CA228044 · NCI · STANFORD UNIVERSITY · PI LI, LINGYIN · 2017 to 2017
$2.4M
NCI NIH HHS DP2 CA228044NCI NIH HHS DP2 CA239597NCI NIH HHS P01 CA210961NCI NIH HHS R01 CA258427
6 · The paper itself

Abstract

ENPP1 expression correlates with poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant hydrolase of extracellular cGAMP: a cancer-cell-produced immunotransmitter that activates the anticancer STING pathway. However, ENPP1 has other catalytic activities and the molecular and cellular mechanisms contributing to its tumorigenic effects remain unclear. Here, using single cell RNA-seq (scRNA-seq), we show that ENPP1 overexpression drives primary breast tumor growth and metastasis by synergistically dampening extracellular cGAMP-STING mediated antitumoral immunity and activating immunosuppressive extracellular adenosine (eADO) signaling. In addition to cancer cells, stromal and immune cells in the tumor microenvironment (TME) also express ENPP1 that restrains their response to tumor-derived cGAMP.

Identifiers

PMID37333273
PMCPMC10274658
OpenAlexW4379390216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.