Evidence map›Paper›PMID 37333267›Full record

ArticlebioRxiv : the preprint server for biology2023

Impaired cerebellar plasticity hypersensitizes sensory reflexes in

Chenyu Wang, Kimberly D Derderian, Elizabeth Hamada, Xujia Zhou, Andrew D Nelson, Henry Kyoung, Nadav Ahituv, Guy Bouvier, Kevin J Bender

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chenyu WangNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Kimberly D DerderianDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Elizabeth HamadaDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Xujia ZhouDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Andrew D NelsonDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Henry KyoungDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Nadav AhituvWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Guy BouvierDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Kevin J BenderDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

The function of SCN2A in neocortexR01MH125978 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BENDER, KEVIN J · 2021 to 2025
$2.0M
Convergent cellular and network mechanisms of ASD risk genesK99MH135209 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NELSON, ANDREW D · 2024 to 2025
$234k
Cellular Mechanisms of Convergence Among Autism Spectrum Disorder GenesF32MH125536 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NELSON, ANDREW D · 2021 to 2023
$153k
NIMH NIH HHS F32 MH125536NIMH NIH HHS K99 MH135209NIMH NIH HHS R01 MH125978
6 · The paper itself

Abstract

Children diagnosed with autism spectrum disorder (ASD) commonly present with sensory hypersensitivity, or abnormally strong reactions to sensory stimuli. Such hypersensitivity can be overwhelming, causing high levels of distress that contribute markedly to the negative aspects of the disorder. Here, we identify the mechanisms that underlie hypersensitivity in a sensorimotor reflex found to be altered in humans and in mice with loss-of-function in the ASD risk-factor gene

Identifiers

PMID37333267
PMCPMC10274749
OpenAlexW4379745934

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.