Evidence map›Paper›PMID 37333155›Full record

ArticlebioRxiv : the preprint server for biology2023

Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization and de novo cell types.

Joseph C Maggiore, Ryan LeGraw, Aneta Przepiorski, Jeremy Velazquez, Christopher Chaney, Evan Streeter, Anne Silva-Barbosa, Jonathan Franks, Joshua Hislop, Alex Hill and 15 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 7 institutions in 3 countries.

Joseph C MaggioreDepartment of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
Ryan LeGrawDepartment of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
Aneta PrzepiorskiDepartment of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
Jeremy VelazquezDepartment of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
Christopher ChaneyDepartment of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Evan StreeterDepartment of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
Anne Silva-BarbosaDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh PA, 15213.
Jonathan FranksCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Joshua HislopPittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Alex HillDepartment of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
Haojia WuDivision of Nephrology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63130.
Katherine PfisterDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh PA, 15213.
Sara E HowdenMurdoch Children's Research Institute, Melbourne, Victoria, Australia.
Simon C WatkinsCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Melissa LittleMurdoch Children's Research Institute, Melbourne, Victoria, Australia.
Benjamin D HumphreysDivision of Nephrology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63130.
Alan WatsonCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Donna B StolzCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Samira KianiDepartment of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
Alan J DavidsonDepartment of Molecular Medicine and Pathology, University of Auckland, Auckland 1010, New Zealand.
Thomas J CarrollDepartment of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ondine CleaverDepartment of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390.
Sunder Sims-LucasDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh PA, 15213.
Mo R EbrahimkhaniDepartment of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
Neil A HukriedeDepartment of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
University of Pittsburgh · USThe University of Texas Southwestern Medical Center · USWashington University in St. Louis · USMurdoch Children's Research Institute · AUSouthwestern Medical Center · USThe University of Melbourne · AUUniversity of Auckland · NZ

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARATTINO, MARCELO DANIEL · 2008 to 2022
$13.4M
Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shuchang Silvia Liu · 2019 to 2026
$10.9M
Application of Progenitor Niche Signals to Ex Vivo NephrogenesisRC2DK125960 · NIDDK · ROGOSIN INSTITUTE · PI CARROLL, THOMAS JOSEPH, CLEAVER, ONDINE B · 2021 to 2025
$7.4M
Cellular Approaches to Tissue Engineering/RegenerationT32EB001026 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN, ANDREW W, MONGA, SATDARSHAN SINGH · 2003 to 2024
$5.5M
Therapeutic Optimization of Productive Repair After Acute Kidney InjuryUC2DK126122 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVIDSON, ALAN, DE CAESTECKER, MARK P. · 2020 to 2024
$3.2M
The Role of Renal Interstitium in Kidney DevelopmentR01DK127634 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI CARROLL, THOMAS JOSEPH, PARK, JOO-SEOP · 2021 to 2024
$2.8M
Recreating Human Developmental Hematopoietic Niches for Ex Vivo Biomanufacturing of Blood Stem CellsR01HL141805 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mo Reza Ebrahimkhani · 2019 to 2026
$2.6M
Integration of systems and synthetic biology to advance development of human tissues ex vivoR01EB028532 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EBRAHIMKHANI, MO REZA · 2019 to 2022
$1.7M
CRISPR logic circuits for safer and controllable gene therapiesR01EB024562 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KIANI, SAMIRA · 2018 to 2021
$1.7M
Request for a Nikon A1 confocal microscopeS10OD019973 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2015 to 2015
$358k
NHLBI NIH HHS R01 HL141805NIBIB NIH HHS R01 EB024562NIBIB NIH HHS R01 EB028532NIBIB NIH HHS T32 EB001026NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK127634NIDDK NIH HHS RC2 DK125960NIDDK NIH HHS UC2 DK126122NIH HHS S10 OD019973
6 · The paper itself

Abstract

Vascularization plays a critical role in organ maturation and cell type development. Drug discovery, organ mimicry, and ultimately transplantation in a clinical setting thereby hinges on achieving robust vascularization of

Indexed as

endothelialGenetic engineeringorganoidspodocytesreninscRNAseq

Identifiers

PMID37333155
PMCPMC10274893
OpenAlexW4378833691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.