Evidence map›Paper›PMID 37333144›Full record

ArticlebioRxiv : the preprint server for biology2023

Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes.

A T Nelson, M E Cicardi, S S Markandaiah, J Han, N Philp, E Welebob, A R Haeusler, P Pasinelli, G Manfredi, H Kawamata and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

A T NelsonWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
M E CicardiWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
S S MarkandaiahWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
J HanDepartment of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
N PhilpDepartment of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
E WelebobWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
A R HaeuslerWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
P PasinelliWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
G ManfrediFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, New York 10065, USA.
H KawamataFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, New York 10065, USA.
D TrottiWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Thomas Jefferson University · USCornell University · US

Funding

Mitochondrial Integrated Stress Response in Neurological DiseasesR35NS122209 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Giovanni Manfredi · 2021 to 2026
$6.6M
Exosome-mediated propagation of disease linked poly-dipeptides in C9orf72-FTD/ALSRF1AG057882 · NIA · THOMAS JEFFERSON UNIVERSITY · PI TROTTI, DAVIDE, YANG, YONGJIE · 2018 to 2018
$3.6M
The pathogenic relationship between neuronal activity and C9orf72-linked neurodegenerationRF1NS114128 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI HAEUSLER, AARON RAYMOND · 2020 to 2021
$2.5M
Contribution of astrocytes to mutant FUS-linked Amyotrophic Lateral SclerosisR01NS109150 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI PASINELLI, PIERA · 2019 to 2023
$1.7M
Development of a mouse model of C9ORF72 ALS/FTD expressing RAN translated peptideR21NS090912 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI TROTTI, DAVIDE · 2014 to 2015
$428k
Metabolic perturbations as a modifier of repeat-associated non-AUG translation in C9orf72-linked ALS/FTDF31NS118838 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI NELSON, ANDREW · 2020 to 2021
$92k
NIA NIH HHS RF1 AG057882NINDS NIH HHS F31 NS118838NINDS NIH HHS R01 NS109150NINDS NIH HHS R21 NS090912NINDS NIH HHS R35 NS122209NINDS NIH HHS RF1 NS114128
6 · The paper itself

Abstract

The most prevalent genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia is a (GGGGCC)

Indexed as

ALSC9orf72Dipeptide Repeat ProteinsFTDGlucose HypometabolismRAN Translation

Identifiers

PMID37333144
PMCPMC10274806
OpenAlexW4379616889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.