Evidence map›Paper›PMID 37332790›Full record

ArticleACS omega2023

Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins.

Heli Tirkkonen, Katelyn V Brown, Magdalena Niemczura, Zélie Faudemer, Courtney Brown, Larissa V Ponomareva, Yosra A Helmy, Jon S Thorson, S Eric Nybo, Mikko Metsä-Ketelä and 1 more

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Synthetic and systems biotechnology · 2026
    Review
  2. Article
  3. Article
  4. Antibiotic Alternatives and Next-Generation Therapeutics forAntibiotics (Basel, Switzerland) · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Heli TirkkonenDepartment of Life Technologies, University of Turku, FIN-20014 Turku, Finland.ORCID https://orcid.org/0000-0002-9913-226X
Katelyn V BrownDepartment of Pharmaceutical Sciences, College of Pharmacy, Ferris State University, Big Rapids, Michigan 49307, United States.
Magdalena NiemczuraDepartment of Life Technologies, University of Turku, FIN-20014 Turku, Finland.
Zélie FaudemerChemistry and Chemical Engineering Department, SIGMA Clermont, 63170 Aubière, France.
Courtney BrownDepartment of Pharmaceutical Sciences, College of Pharmacy, Ferris State University, Big Rapids, Michigan 49307, United States.
Larissa V PonomarevaCenter for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Yosra A HelmyDepartment of Veterinary Science, College of Agriculture, Food, and Environment, University of Kentucky, Lexington, Kentucky 40546, United States.
Jon S ThorsonCenter for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.ORCID https://orcid.org/0000-0002-7148-0721
S Eric NyboDepartment of Pharmaceutical Sciences, College of Pharmacy, Ferris State University, Big Rapids, Michigan 49307, United States.ORCID https://orcid.org/0000-0001-7884-7787
Mikko Metsä-KeteläDepartment of Life Technologies, University of Turku, FIN-20014 Turku, Finland.ORCID https://orcid.org/0000-0003-3176-2908
Khaled A ShaabanCenter for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.ORCID https://orcid.org/0000-0001-7638-4942
University of Kentucky · USFerris State University · USUniversity of Turku · FISigma Clermont · FR

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Understanding the role of anti-apolipoprotein A-I antibodies in atherosclerotic cardiovascular diseaseP20GM130456 · NIGMS · UNIVERSITY OF KENTUCKY · PI M. Ashfaqul Alam · 2020 to 2026
$18.7M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
In Vitro Glycorandomization of Natural ProductsR37AI052218 · NIAID · UNIVERSITY OF KENTUCKY · PI THORSON, JON SCOTT · 2012 to 2021
$4.0M
Bruker AVANCE NEO 600 MHz High-Performance Digital NMR SpectrometerS10OD028690 · OD · UNIVERSITY OF KENTUCKY · PI GARNEAU-TSODIKOVA, SYLVIE · 2020 to 2020
$1.4M
Combinatorial biosynthesis and metabolism studies of novel tetracenomycinsR15CA252830 · NCI · FERRIS STATE UNIVERSITY · PI NYBO, ERIC · 2020 to 2020
$385k
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR001998NCI NIH HHS R15 CA252830NIAID NIH HHS R37 AI052218NIGMS NIH HHS P20 GM130456NIH HHS S10 OD028690
6 · The paper itself

Abstract

Tetracenomycins and elloramycins are polyketide natural products produced by several actinomycetes that exhibit antibacterial and anticancer activities. They inhibit ribosomal translation by binding in the polypeptide exit channel of the large ribosomal subunit. The tetracenomycins and elloramycins are typified by a shared oxidatively modified linear decaketide core, yet they are distinguished by the extent of O-methylation and the presence of a 2',3',4'-tri

Identifiers

PMID37332790
PMCPMC10269268
OpenAlexW4379053156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.