SynthesisFrontiers in medicine2023
Association between obstructive sleep apnea and resistant hypertension: systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Effects of Continuous Positive Airway Pressure on Surrogate, Intermediate, and Functional Cardiovascular Outcomes in Obstructive Sleep Apnea: An Umbrella Review of Systematic Reviews and Meta-Analyses.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Efficacy and safety of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea: an overview of systematic reviews and meta analyses.Frontiers in medicine · 2026Pooled it
- CagriSema Reduces Blood Pressure in Adults With Overweight or Obesity: REDEFINE 1.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Sex Differences in Sleep Duration and Quality: Implications for Hypertension Risk.Current hypertension reports · 2026Review
- Association between high likelihood of obstructive sleep apnea and masked hypertension: findings from the Jackson heart and coronary artery risk development in young adults studies.Journal of hypertension · 2026Article
- Prevalence of Obstructive Sleep Apnea Syndrome in Patients with Resistant Hypertension.Journal of clinical medicine · 2026Article
- Association of bedtime with co-morbid hypertension in OSA: a community-based study.Sleep & breathing = Schlaf & Atmung · 2026Article
- The Hidden Burden of COMISA in Hypertensive Obstructive Sleep Apnea Patients.Anatolian journal of cardiology · 2026Article
- Beyond Sleep: The Cardiovascular Impact of Obstructive Sleep Apnea Syndrome.Journal of clinical medicine · 2026Article
- The Prevalence and Characteristics of Obstructive Sleep Apnea Among Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis.Journal of central nervous system disease · 2026Article
- Association between minimum nocturnal heart rate and cerebral small vessel disease in patients with obstructive sleep apnea.Frontiers in aging neuroscience · 2026Article
- The Effect of Chronotherapy on Clinical Outcomes in Hypertensive Patients: A Systematic Review and Meta-Analysis Comparing Bedtime Versus Morning Dosing of Antihypertensive Drugs.Health science reports · 2026Review
- Resistant hypertension: Epidemiology, mechanisms and contemporary therapeutic strategies.Heart international · 2026Review
- 2024 Thai guidelines on the treatment of hypertension.Asian biomedicine : research, reviews and news · 2025Article
- Sleep Apnea: The Slept-Upon Cardiovascular Risk Factor.Biomedicines · 2025Review
- Relationship between Quality of Life and Swallowing in Hypertensive Individuals with Obstructive Sleep Apnea.Dysphagia · 2025Observational
- Long-term effect of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea.Journal of human hypertension · 2025Article
- Association of Obstructive Sleep Apnea and Uncontrolled Hypertension in the Middle Aged 40-59 in Korean Population.Journal of Korean medical science · 2025Article
- Prevalence and determinants of apparent treatment-resistant hypertension among patients in South African primary care: a single-centre observational study.BMC cardiovascular disorders · 2025Observational
- Rate of Screening for Obstructive Sleep Apnea Syndrome in Patients with Apparent Resistant Hypertension Attending a Tertiary Care Hospital.Oman medical journal · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Obstructive sleep apnea syndrome (OSAS) is a chronic disorder characterized by recurring episode obstruction and collapse of upper airways during sleep, leading to hypoxia and sleep disruption. OSAS is commonly associated with an increased prevalence of hypertension. The underlying mechanism in OSA with hypertension is related to intermittent hypoxia. This hypoxia induces endothelial dysfunction, overactivity of sympathetic effects, oxidative stress, and systemic inflammation. Hypoxemia triggers the sympathetic process's overactivity, leading to the development of resistant hypertension in OSA. Thus, we hypothesize to evaluate the association between resistant hypertension and OSA. Methods: The PubMed, ClinicalTrails.gov, CINAHL, Google Scholar, Cochrane Library, and Science Direct databases were searched from 2000 to January 2022 for studies demonstrating the association between resistant hypertension and OSA. The eligible articles underwent quality appraisal, meta-analysis, and heterogeneity assessment. Results: This study comprises seven studies, including 2,541 patients ranged from 20 to 70 years. The pooled analysis of six studies demonstrated that OSAS patients with a history of increased age, gender, obesity, and smoking status are at an increased risk for resistant hypertension (OR: 4.16 [3.07, 5.64], Conclusion: This study concludes that OSAS patients with or without related risk factors demonstrated increased risk for resistant hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.