Evidence map›Paper›PMID 37332637›Full record

ArticleMovement disorders clinical practice2023

Course of Impulse Control Disorder Symptoms in Parkinson's Disease: Deep Brain Stimulation Versus Medications.

Pilar Hernandez-Con, Iris Lin, Eugenia Mamikonyan, Wissam Deeb, Robert Feldman, Andrew Althouse, Ryan Barmore, Robert S Eisinger, Meredith Spindler, Michael S Okun and 2 more

Open access · greenAbstract read
In one paragraph

Article in Movement disorders clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Impulse control and related behavioral disorders in Parkinson's disease. Risk factors, diagnosis, and management. Is there a possible role for non-invasive brain stimulation?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  6. Article
  7. Article
  8. Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Pilar Hernandez-ConDepartment of Pharmaceutical Outcomes and Policy University of Florida Gainesville Florida USA.
Iris LinDepartment of Neurology University of Cincinnati Cincinnati Ohio USA.
Eugenia MamikonyanDepartment of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA.
Wissam DeebDepartment of Neurology University of Massachusetts Amherst Massachusetts USA.
Robert FeldmanCenter for Research on Health Care Data Center University of Pittsburgh Pittsburgh Pennsylvania USA.
Andrew AlthouseCenter for Research on Health Care Data Center University of Pittsburgh Pittsburgh Pennsylvania USA.
Ryan BarmoreDepartment of Neurology Banner Health Phoenix Arizona USA.
Robert S EisingerDepartment of Neurology University of Pennsylvania Philadelphia Pennsylvania USA.
Meredith SpindlerDepartment of Neurology University of Pennsylvania Philadelphia Pennsylvania USA.
Michael S OkunDepartment of Neurology Norman Fixel Institute for Neurological Diseases, University of Florida Gainesville Florida USA.
Daniel WeintraubDepartment of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA.ORCID https://orcid.org/0000-0003-0633-7168
Lana M ChahineDepartment of Neurology University of Pittsburgh Pittsburgh Pennsylvania USA.ORCID https://orcid.org/0000-0003-2521-7196
University of Florida · USUniversity of Pennsylvania · USUniversity of Pittsburgh · USBanner Health · USUniversity of Cincinnati · USUniversity of Massachusetts Amherst · US

Funding

Clinical Pharmacoepidemiology Training ProgramT32GM075766 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Sean Hennessy, Charles Edward Leonard · 2006 to 2026
$8.4M
NIGMS NIH HHS T32 GM075766
6 · The paper itself

Abstract

Background: The effect of surgery on impulse control disorders (ICDs) remains unclear in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS). Objective: To examine changes in ICD symptoms in PD patients undergoing DBS compared to a medication-only control group. Methods: The study was a 2-center, 12-month, prospective, observational investigation of PD patients undergoing DBS and a control group matched on age, sex, dopamine agonist use, and baseline presence of ICDs. Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) and total levodopa equivalent daily dose (LEDD) were collected at baseline, 3, 6, and 12 months. Linear mixed-effects models assessed changes in mean QUIP-RS score (sum of buying, eating, gambling, and hypersexuality items). Results: The cohort included 54 participants (DBS = 26, controls = 28), mean (SD) age 64.3 (8.1) and PD duration 8.0 (5.2) years. Mean baseline QUIP-RS was higher in the DBS group at baseline (8.6 (10.7) vs. 5.3 (6.9), Conclusions: ICD symptoms (including de novo symptoms) at 12 months follow-up were similar between PD patients undergoing DBS and patients treated with pharmacological therapy only. Monitoring for emergence of ICD symptoms is important in both surgically- and medication-only-treated PD patients.

Indexed as

deep brain stimulationde novo ICDsdopaminergic medicationLEDDParkinson's disease

Identifiers

PMID37332637
PMCPMC10272921
OpenAlexW4366572688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.