Evidence map›Paper›PMID 37332611›Full record

ArticleiScience2023

Sequential disruptions to inflammatory and angiogenic pathways and risk of spontaneous preterm birth in Malawian women.

Andrea M Weckman, Robyn E Elphinstone, John M Ssenkusu, Vanessa Tran, Kathleen Zhong, Mwayiwawo Madanitsa, Carole Khairallah, Linda Kalilani-Phiri, Victor Mwapasa, Andrea L Conroy and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 5 countries.

Andrea M WeckmanDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Robyn E ElphinstoneSAR Laboratories, Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, Toronto, ON, Canada.
John M SsenkusuDepartment of Epidemiology and Biostatistics, School of Public Health, Makerere University, Kampala, Uganda.
Vanessa TranDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Kathleen ZhongSAR Laboratories, Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, Toronto, ON, Canada.
Mwayiwawo MadanitsaCollege of Medicine, University of Malawi, Blantyre, Malawi.
Carole KhairallahDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Linda Kalilani-PhiriCollege of Medicine, University of Malawi, Blantyre, Malawi.
Victor MwapasaCollege of Medicine, University of Malawi, Blantyre, Malawi.
Andrea L ConroyDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Feiko O Ter KuileDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Chloe R McDonaldSAR Laboratories, Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, Toronto, ON, Canada.
Kevin C KainDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
University Health Network · CAUniversity of Malawi · MWLiverpool School of Tropical Medicine · GBIndiana University School of MedicineMakerere University · UG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preterm birth is a leading cause of death in children under five years of age. We hypothesized that sequential disruptions to inflammatory and angiogenic pathways during pregnancy increase the risk of placental insufficiency and spontaneous preterm labor and delivery. We conducted a secondary analysis of inflammatory and angiogenic analytes measured in plasma samples collected across pregnancy from 1462 Malawian women. Women with concentrations of the inflammatory markers sTNFR2, CHI3L1, and IL18BP in the highest quartile before 24 weeks gestation and women with anti-angiogenic factors sEndoglin and sFlt-1/PlGF ratio in the highest quartile at 28-33 weeks gestation had an increased relative risk of preterm birth. Mediation analysis further supported a potential causal link between early inflammation, subsequent angiogenic dysregulation detrimental to placental vascular development, and earlier gestational age at delivery. Interventions designed to reduce the burden of preterm birth may need to be implemented before 24 weeks of gestation.

Indexed as

Clinical findingHealth sciencesPregnancy

Identifiers

PMID37332611
PMCPMC10275952
OpenAlexW4377115559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.